Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor imp... by Rasneer S. Bains, Hamish Forrest, Rowland R. Sillito, J. Douglas Armstrong, J. Douglas Armstrong, Michelle Stewart, Patrick M. Nolan, Sara E. Wells

“…Integrating cage-floor activity with cage-lid activity (climbing) has the potential to greatly enhance the characterization of mouse strains, detecting early and subtle signs of disease and increasing reproducibility in preclinical studies.…”
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A Comparison of Solvent-Based Extraction Methods to Assess the Central Carbon Metabolites in Mouse Bone and Muscle by Daniela B. Dias, Raphaela Fritsche-Guenther, Friederike Gutmann, Georg N. Duda, Jennifer Kirwan, Patrina S. P. Poh

“…Furthermore, mBD, mBD-low, and mMat were sufficiently sensitive in detecting polar metabolites extracted from mouse muscle; however, they lacked repeatability. …”
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Oligonucleotide Enhancing Compound Increases Tricyclo-DNA Mediated Exon-Skipping Efficacy in the Mdx Mouse Model by Flavien Bizot, Abdallah Fayssoil, Cécile Gastaldi, Tabitha Irawan, Xaysongkhame Phongsavanh, Arnaud Mansart, Thomas Tensorer, Elise Brisebard, Luis Garcia, Rudolph L Juliano, Aurélie Goyenvalle

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Identification of Novel Fusion Genes in Bone and Soft Tissue Sarcoma and Their Implication in the Generation of a Mouse Model by Yasuyo Teramura, Miwa Tanaka, Yukari Yamazaki, Kyoko Yamashita, Yutaka Takazawa, Keisuke Ae, Seiichi Matsumoto, Takayuki Nakayama, Takao Kaneko, Yoshiro Musha, Takuro Nakamura

“…These fusions are usually disease type-specific, and identification of the fusion genes greatly helps in making precise diagnoses and determining therapeutic directions. …”
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Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1 Mouse Model for Chronic Lymphocytic Leukemia by Thomas Parigger, Franz Josef Gassner, Christian Scherhäufl, Aryunni Abu Bakar, Jan Philip Höpner, Alexandra Hödlmoser, Markus Steiner, Kemal Catakovic, Roland Geisberger, Richard Greil, Nadja Zaborsky

“…The reinvigoration of anti-cancer immunity by immune checkpoint therapies has greatly improved cancer treatment. In chronic lymphocytic leukemia (CLL), patients as well as in the Tcl1 mouse model for CLL, PD1-expressing, exhausted T cells significantly expand alongside CLL development; nevertheless, PD1 inhibition has no clinical benefit. …”
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The characterization of a mouse model of transient stroke using ex vivo MR microscopy and in vivo MR imaging by Huang, Shuning, Ph. D. Massachusetts Institute of Technology

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Roles of taurine-mediated tonic GABAA receptor activation in the radial migration of neurons in the fetal mouse cerebral cortex by Tomonori eFurukawa, Junko eYamada, Tenpei eAkita, Yoshitaka eMatsushima, Yuchio eYanagawa, Atsuo eFukuda

“…In a taurine-deficient mouse model, the GABAAR-mediated tonic currents were greatly reduced, and radial migration was accelerated. …”
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Smartphone-Based Portable Bioluminescence Imaging System Enabling Observation at Various Scales from Whole Mouse Body to Organelle by Mitsuru Hattori, Sumito Shirane, Tomoki Matsuda, Kuniaki Nagayama, Takeharu Nagai

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Safety, Immunogenicity, and Protective Efficacy of a Chimeric A/B Live Attenuated Influenza Vaccine in a Mouse Model by Ekaterina Stepanova, Elena Krutikova, Pei-Fong Wong, Victoria Matyushenko, Ekaterina Bazhenova, Irina Isakova-Sivak, Larisa Rudenko

“…IFNγ-secreting CD8 effector memory T cells (CD44⁺CD62L⁻) were detected in mouse splenocytes after stimulation with the specific influenza A peptide (NP₃₆₆); however, the T-cell response was not sufficient to protect animals against infection with a high-dose mouse-adapted A/California/07/2009 (H1N1pdm09) virus, most probably due to the mismatch of key T-cell epitopes of the H1N1 virus and the LAIV backbone. …”
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Cloning, Expression, Monoclonal Antibody Preparation of Human Gene NBEAL1 and Its Application in Targeted Imaging of Mouse Glioma by Chenchen Bao, Hao Yang, Ping Sheng, Juxiang Chen, Hua Song, Xuehua Ding, Bin Liu, Yicheng Lu, Guohan Hu, Daxiang Cui

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Indirubin alleviates CCl4-induced liver fibrosis by regulation of TGF-β-mediated signaling pathways by Xiaoying Li, Yuanzhi Yao, Lin Wei

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MircoRNA-322-5p promotes lipopolysaccharide-induced acute kidney injury mouse models and mouse primary proximal renal tubular epithelial cell injury by regulating T-box transcripti... by Xiaobing Ji, Xiaodong Liu, Xiangxiang Li, Xin Du, Li Fan

“…Introduction and objectives: Acute kidney injury (AKI) is a common devastating complication characterized by an abrupt loss of renal function. It is of great significance to explore promising biomarkers for AKI treatment. …”
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MicroRNA-322-5p promotes lipopolysaccharide-induced acute kidney injury mouse models and mouse primary proximal renal tubular epithelial cell injury by regulating T-box transcripti... by Xiaobing Ji, Xiaodong Liu, Xiangxiang Li, Xin Du, Li Fan

“…Introduction and objectives: Acute kidney injury (AKI) is a common devastating complication characterized by an abrupt loss of renal function. It is of great significance to explore promising biomarkers for AKI treatment. …”
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4mCPred-CNN—Prediction of DNA N4-Methylcytosine in the Mouse Genome Using a Convolutional Neural Network by Zeeshan Abbas, Hilal Tayara, Kil To Chong

“…To know different its biological functions, the accurate detection of 4mC sites is required. Although we have several techniques for the prediction of 4mC sites in different genomes based on both machine learning (ML) and convolutional neural networks (CNNs), there is no CNN-based tool for the identification of 4mC sites in the mouse genome. …”
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The synthesis of a novel molecular imaging probe 68Ga-DOTA-PDL1P and application in mouse model of melanoma by YANG Ziyi, LI Panli, GU Bingxin, LIU Cheng, SONG Shaoli, XU Xiaoping

“…Background and purpose: The immunogenic drugs represented by programmed cell death 1 (PD-1) and programmed death ligand-1 (PD-L1) have achieved great success in clinic. However, with the development of clinical application, the overall effective rate varies greatly. …”
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A Multifunctional Integrated Metal‐Free MRI Agent for Early Diagnosis of Oxidative Stress in a Mouse Model of Diabetic Cardiomyopathy by Zhuang Nie, Kun Zhang, Xinyu Chen, Jingxin Wang, Huile Gao, Bingwen Zheng, Qihong Wu, Yingkun Guo, Xiangyang Liu, Xu Wang

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Molecular magnetic resonance imaging of acute vascular cell adhesion molecule-1 expression in a mouse model of cerebral ischemia. by Hoyte, L, Brooks, K, Nagel, S, Akhtar, A, Chen, R, Mardiguian, S, McAteer, M, Anthony, D, Choudhury, R, Buchan, A, Sibson, N

“…The pathogenesis of stroke is multifactorial, and inflammation is thought to have a critical function in lesion progression at early time points. Detection of inflammatory processes associated with cerebral ischemia would be greatly beneficial in both designing individual therapeutic strategies and monitoring outcome. …”

Investigation into multifunctional nanoparticles for the detection, imaging and intervention of amyloid by Xia, Yang

“…However, it is often too late for intervention when the symptoms are detectable and there is no effective treatment for AD. …”
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Extracellular Vesicles Secreted by Human Urine-Derived Stem Cells Promote Ischemia Repair in a Mouse Model of Hind-Limb Ischemia by Qingwei Zhu, Qing Li, Xin Niu, Guowei Zhang, Xiaozheng Ling, Jieyuan Zhang, Yang  Wang, Zhifeng Deng

“…Background/Aims: Our previous studies have shown that human urine-derived stem cells (USCs) have great potential as a cell source for cytotherapy and tissue engineering and that extracellular vesicles (EVs) secreted by USCs (USCs-EVs) can prevent diabetes-induced kidney injury in an animal model. …”
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Protective Efficacy Evaluation of NPt-NPt-VP1₁₋₁₀₀Protein as a Candidate Vaccine Against Enterovirus 71 Infections in Mouse Model by Ch'ng, Wei Choong

“…NPt-VP11-100 protein therefore offers a great promise towards finding a vaccine for EV71 infections.…”
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