AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation by Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang, Jinhong Chen

“…Abstract Background Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. …”
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In Situ Real-Time Monitoring of Glutamate and Electrophysiology from Cortex to Hippocampus in Mice Based on a Microelectrode Array by Xinyi Fan, Yilin Song, Yuanlin Ma, Song Zhang, Guihua Xiao, Lili Yang, Huiren Xu, Dai Zhang, Xinxia Cai

“…Since the function of the hippocampus depends heavily on the glutamate (Glu) signaling pathways, in situ real-time detection of Glu neurotransmitter release and electrophysiological signals in hippocampus is of great significance. …”
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Profiling of amines in biological samples using polythioester-functionalized magnetic nanoprobe by Yuming Qiu, Mo Zhang, Zhizhen Lai, Renjun Zhang, Hongtao Tian, Shuai Liu, Dan Li, Jiang Zhou, Zhili Li

“…With the introduction of polythioester, PMPs demonstrate remarkably increased capture efficiency, leading to the dramatically improved sensitivity of mass spectrometry detection.Results: The analysis method with PMPs treatment has been applied in rapid detection of more than 100 amines in lung adenocarcinoma cell lines, mouse organ tissues, and 103 human serum samples with high-throughput and high-coverage. …”
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Toll-like receptors and malaria – sensing and susceptibility by M Eriksson, E, Schofield, L

“…Of the ten human and twelve mouse TLRs, TLR2, TLR4, TLR7 and TLR9 are known to detect malarial antigens and induce anti-malarial immune responses. …”

Humanised Mice and Immunodeficient Mice (NSG) Are Equally Sensitive for Prediction of Stem Cell Malignancy in the Teratoma Assay by Monika Bialecka, Joaquin Montilla-Rojo, Bernard A. J. Roelen, Ad J. Gillis, Leendert H. J. Looijenga, Daniela. C. F. Salvatori

“…The use of human pluripotent stem cells (hPSCs) in regenerative medicine has great potential. However, it is important to exclude that these cells can undergo malignant transformation, which could lead to the development of malignant tumours. …”
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A Novel KRAS Antibody Highlights a Regulation Mechanism of Post-Translational Modifications of KRAS during Tumorigenesis by Mohamad Assi, Boris Pirlot, Vincent Stroobant, Jean-Paul Thissen, Patrick Jacquemin

“…In addition, KRAS was sensitively detected in a mouse tissue electroporated with an expression vector. …”
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Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including Amyloid beta Precursor Protein by Deussing Jan M, Panhuysen Markus, Trümbach Dietrich, Pütz Benno, Czibere Ludwig, Tsolakidou Amalia, Wurst Wolfgang, Sillaber Inge, Landgraf Rainer, Holsboer Florian, Rein Theo

“…Although the expression changes between the mouse strains were quite different, they unfolded in phases over time in both strains. …”
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Cholesterol metabolism is a potential therapeutic target in Duchenne muscular dystrophy by Fatima Amor, Ai Vu Hong, Guillaume Corre, Mathilde Sanson, Laurence Suel, Stephanie Blaie, Laurent Servais, Thomas Voit, Isabelle Richard, David Israeli

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Intraocular RGD-Engineered Exosomes and Active Targeting of Choroidal Neovascularization (CNV) by Dimitrios Pollalis, Dongin Kim, Gopa Kumar Gopinadhan Nair, Changsun Kang, Arjun V. Nanda, Sun Young Lee

“…Exosome markers were confirmed using an exosome detection antibody array. Intravitreal injection of fluorescent (PKH-26)-labeled or engineered ASL exosomes (1 × 10⁶ exosomes/μL) were given to the wild-type mouse or laser-induced CNV mouse model. …”
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High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator by Qiangzhou Rong, Youngseop Lee, Yuqi Tang, Tri Vu, Carlos Taboada, Wenhan Zheng, Jun Xia, David A. Czaplewski, Hao F. Zhang, Cheng Sun, Junjie Yao

“…3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. …”
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The association between TIPARP gene polymorphisms rs2665390 and ovarian cancer susceptibility by Maryam vahidi, Massoud Houshmand, Mahdieh Banoei, Farid Heidari

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TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma by Tingting Feng, Wei Zhou, Lu Yin, Lin Zhou, Haiyang Xie, Shusen Zheng, Xiao Xu, Sunbin Ling, Qifan Zhan, Shengjun Xu, Kangchen Chen, Jimin Liu, Shuai Wang, Yuchen Liu, Xuyong Wei, Lincheng Zhang, Jiongjie Yu, Jiachen Hong, Qingyang Que, Yongfeng Wu, Jiaqi Bao, Nan Xu, Zhikun Liu

“…Background Immunotherapy has facilitated great breakthroughs in the treatment of hepatocellular carcinoma (HCC). …”
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Studies on the surface antigens and surface properties of animal cell heterokaryons by Grace, D

“…HeLa cells of human origin were fused with mouse Ehrlich ascites cells, mouse L strain fibroblasts, hen and chick erythrocytes, rat lymphocytes, chick fibroblasts, and mouse and rabbit macrophages. …”

Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging by Caroline Guglielmetti, Tanguy Boucneau, Peng Cao, Annemie Van der Linden, Peder E.Z. Larson, Myriam M. Chaumeil

“…Although magnetic resonance imaging (MRI) is the gold standard method to diagnose and monitor MS patients, clinically available MRI protocols show limited specificity for myelin detection, notably in cerebral grey matter areas. Ultrashort echo time (UTE) MRI has shown great promise for direct imaging of lipids and myelin sheaths, and thus holds potential to improve lesion detection.In this study, we used a sequence combining magnetization transfer (MT) with UTE (“UTE-MT”, TE ​= ​76 ​μs) and with short TE (“STE-MT”, TE ​= ​3000 ​μs) to evaluate spatial and temporal changes in brain myelin content in the cuprizone mouse model for MS on a clinical 7 ​T scanner. …”
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High Sensitivity and Wide Linearity LC-MS/MS Method for Oxylipin Quantification in Multiple Biological Samples by Xian Fu, Hou-Hua Yin, Ming-Jun Wu, Xin He, Qing Jiang, Ling-Tong Zhang, Jun-Yan Liu

“…Due to the high sensitivity, while reducing sample consumption to below half the volume of previous methods, 74, 78, and 59 low-abundance oxylipins, among which some were difficult to detect like lipoxins and resolvins, were well quantified in the tested mouse plasma, mouse liver, and human plasma samples, respectively. …”
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Dapagliflozin promotes angiogenesis in hindlimb ischemia mice by inducing M2 macrophage polarization by Heng Yang, Heng Yang, Wanqi Lan, Wanqi Lan, Wu Liu, Wu Liu, Tingtao Chen, Yanhua Tang

“…Dapagliflozin has shown great potential in the treatment of cardiovascular disease. …”
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Expression of TRAIL and Fas in Primary Hyperparathyroidism by Oliwia Anna Segiet, Mariusz Deska, Łukasz Mielańczyk, Marlena Brzozowa-Zasada, Grzegorz Buła, Jacek Gawrychowski, Romuald Wojnicz

“…In cases of primary hyperparathyroidism, appropriate and prompt diagnosis is of great importance for effective treatment and follow-up. …”
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In vivo imaging of HIF-active tumors by an oxygen-dependent degradation protein probe with an interchangeable labeling system. by Takahiro Kuchimaru, Tetsuya Kadonosono, Shotaro Tanaka, Takashi Ushiki, Masahiro Hiraoka, Shinae Kizaka-Kondoh

“…Therefore, the development of a molecular probe that can detect HIF activity has great potential value for monitoring tumor hypoxia. …”
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“Crosstalk between non-coding RNAs and transcription factor LRF in non-small cell lung cancer” by Magda Spella, Eleftherios Bochalis, Katerina Athanasopoulou, Argyri Chroni, Irene Dereki, Giannoula Ntaliarda, Ifigeneia Makariti, Georgios Psarias, Caterina Constantinou, Vasiliki Chondrou, Argyro Sgourou

“…The epigenetic background holds a great potential for the identification of epi-biomarkers for treatment response however, it is highly complex and requires precise definition as these phenomena are variable between NSCLC subtypes and systems origin.We engaged an in-depth characterization of non-coding (nc)RNAs prevalent in human KRAS-mutant NSCLC cell lines A549 and H460 and mouse KRAS-mutant NSCLC tissue by Next Generation Sequencing (NGS) and quantitative Real Time PCRs (qPCRs). …”
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Recombinant expression of SARS-CoV-2 Receptor Binding Domain (RBD) in Escherichia coli and its immunogenicity in mice by zahra Rahbar, Shahram Nazarian, Ruhollah Dorostkar, Fattah Sotoodehnejadnematalahi, Jafar Amani

“…Results: Indirect ELISA was able to detect the protein RBD in serum of the immunized mouse expressed in E. coli. …”
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