Nano Sized Hydroxyapatite-Polylactic Acid-Vancomycin in Alleviation of Chronic Osteomyelitis by Lv XF, Zhou DM, Sun XH, Zhao Z

“…The cultured osteoblasts were further divided into control, polyethyleneimine (PEI), and nHA-PLA groups to observe their differences in cell proliferation, mineralization, and migration capacities. And a CO mouse model was constructed to detect the anti-CO effect of nHA-PLA-VAN.Results: nHA-PLA-VAN nanocomposites maintained good stability in different acidic solutions, favoring their long-term preservation in vitro. nHA-PLA extended VAN’s half-life by 6-times. …”
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Developing amyloid-β chaperone lipocalin-type prostaglandin D synthase protein as a magnetic resonance active early diagnostic tool by Sharma, Bhargy

“…To this end, we have shown here that L-PGDS protein has great outlook as a diagnostic agent for early identification of AD hallmarks in disease-prone populations, and potential as a therapeutic intervention.…”
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An Optimized Method of Metabolite Extraction from Formalin-Fixed Paraffin-Embedded Tissue for GC/MS Analysis. by Anna Wojakowska, Łukasz Marczak, Karol Jelonek, Krzysztof Polanski, Piotr Widlak, Monika Pietrowska

“…Nevertheless, we proved applicability of FFPE specimens for non-targeted GS/MS-based profiling of tissue metabolome, which is of great importance for feasibility of metabolomics studies using retrospective clinical material.…”
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A quantitative technique to analyze and evaluate microstructures of skin hair follicles based on mueller matrix polarimetry by Shi, Y, Sun, Y, Huang, R, Zhou, Y, Zhai, H, Fan, Z, Ou, Z, Huang, P, He, H, He, C, Wang, Y, Ma, H

“…The results shown in this study suggest that the technique based on Mueller matrix microscopy can realize automatically hair follicle identification, detection, and quantitative evaluation. It has great potential in skin structure-related studies and clinical dermatological applications.…”

Immunochemical activity of <i>Yersinia pseudotuberculosis</i> ompF and ompC porins evaluated by optical trapping by Ilya V. Konyshev, Olga D. Novikova, Olga Yu. Portnyagina, Andrey A. Byvalov

“…Study of features for interacting antigen-antibody system is of great importance for developing new modern tools for diagnostics and therapy of infectious diseases. …”
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Sustained notch signaling inhibition with a gamma-secretase inhibitor prevents traumatic heterotopic ossification by Zheng Wang, Xinzeyu Yi, Chao Jian, Baiwen Qi, Qiaoyun Liu, Zonghuan Li, Aixi Yu

“…Methods: We firstly detected the expressions of Notch target genes in both mouse and human THO samples with quantitative RT-PCR and immunohistochemistry (IHC). …”
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Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice. by Rosas, M, Gordon, S, Taylor, P

“…The ability to detect GM-CSF receptor expression in experimental studies should greatly facilitate the analysis of its role in immune pathologies.…”

Assessing the Attractiveness of Three Baits for Roof Rats in California Citrus Orchards by Kallista N. Wales, Ryan Meinerz, Roger A. Baldwin

“…The identification of baits that are both attractive and readily available would be of great assistance for monitoring changes in roof rat numbers within agricultural fields. …”
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The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes. by Davies, L, Hyde, S, Nunez-Alonso, G, Bazzani, R, Harding-Smith, R, Pringle, I, Lawton, A, Abdullah, S, Roberts, T, McCormick, D, Sumner-Jones, S, Gill, DR

“…Aerosol gene therapy offers great potential for treating acquired and inherited lung diseases. …”

Data-Glove-Based Hand Gesture Recognition System Using Flex Sensors And An Imu Sensor by Ong, Jing Hao

“…With the great expansion of computer technology, Human-Computer Interaction (HCI) is required to be more effective. …”
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Quantitation of Tissue Amyloid via Fluorescence Spectroscopy Using Controlled Concentrations of Thioflavin-S by Tatiana P. MacKeigan, Megan L. Morgan, Peter K. Stys

“…In this study, we developed an optimized ThS staining protocol for the sensitive detection of β-amyloids in the widely used 5xFAD Alzheimer’s mouse model. …”
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Ceritinib is a novel triple negative breast cancer therapeutic agent by Shengli Dong, Hassan Yousefi, Isabella Van Savage, Samuel C. Okpechi, Maryl K. Wright, Margarite D. Matossian, Bridgette M. Collins-Burow, Matthew E. Burow, Suresh K. Alahari

“…Combination therapy of these drugs were investigated using AR positive breast cancer mouse xenograft models. Also, combination treatment of ceritinib and paclitaxel investigated using AR− and AR low mouse xenograft and patient derived xenograft models. …”
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Simple Plasma Test Based on a MoSe2 SERS Platform for the Specific Diagnosis of Alzheimer’s Disease by Yan Zhou, Jianyan Li, Tingting Zheng, Yang Tian

“…In general, the MoSe2 SERS detection platform can well detect the concentration of BD-tau in mouse plasma samples, showing great potential in specific recognition of AD among neurodegenerative diseases.…”
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Investigation of early molecular alterations in tauopathy with generative adversarial networks by Hyerin Kim, Yongjin Kim, Chung-Yeol Lee, Do-Geun Kim, Mookyung Cheon

“…Abstract The recent advances in deep learning-based approaches hold great promise for unravelling biological mechanisms, discovering biomarkers, and predicting gene function. …”
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Ciliated Cells Express a Novel Pattern of Brain-Derived Neurotrophic Factor in Allergic Rhinitis by Fang L, Li CH, Zhang Q, Jiang TJ, Liu Y, Shi FP, Yu P, Yu L, Chen AP, Li T, Wan YZ, Shi L

“…The expression level of BDNF and IL-4/5/13 were detected by RT-PCR. The expressions of BDNF (in serum and NAL fluid), and total-IgE, ovalbumin sIgE (in serum) were detected by ELISA.Results: We found that MFI of BDNF in AR group’s ciliated cells was obviously lower than that in the control group, and a negative correlation was discovered between MFI and VAS score. …”
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Application of a Novel One-Side Cell Quartz Crystal Microbalance Immunosensor in the Determination of Alpha-Fetoprotein from Human Serum by Yan Chen, Huashan Shi, Bo Mu

“…The rapid and accurate detection of alpha-fetoprotein (AFP) levels is of great significance for the diagnosis and later treatment evaluation of liver cancer. …”
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Improved localization of cellular membrane receptors using combined fluorescence microscopy and simultaneous topography and recognition imaging. by Duman, M, Pfleger, M, Zhu, R, Rankl, C, Chtcheglova, L, Neundlinger, I, Bozna, B, Mayer, B, Salio, M, Shepherd, D, Polzella, P, Moertelmaier, M, Kada, G, Ebner, A, Dieudonne, M, Schütz, G, Cerundolo, V, Kienberger, F, Hinterdorfer, P

“…The combination of fluorescence microscopy and atomic force microscopy has a great potential in single-molecule-detection applications, overcoming many of the limitations coming from each individual technique. …”

Gene Expression over Time during Cell Transformation Due to Non-Genotoxic Carcinogen Treatment of Bhas 42 Cells by Kiyomi Ohmori, Asuka Kamei, Yuki Watanabe, Keiko Abe

“…This assay offers the great advantage of enabling the phenotypic detection of oncotransformation. …”
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Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles. by Lu, Q, Rabinowitz, A, Chen, Y, Yokota, T, Yin, H, Alter, J, Jadoon, A, Bou-Gharios, G, Partridge, T

“…Antisense oligonucleotide-mediated alternative splicing has great potential for treatment of Duchenne muscular dystrophy (DMD) caused by mutations within nonessential regions of the dystrophin gene. …”

Noninvasive Near-infrared Imaging of Fluorochromes within the Brains of Live Mice: An In Vivo Phantom Study by Jan Klohs, Jens Steinbrink, Till Nierhaus, Riad Bourayou, Ute Lindauer, Peyman Bahmani, Ulrich Dirnagl, Andreas Wunder

“…Near-infrared fluorescence (NIRF) imaging has great potential for studying physiological and pathophysiological processes noninvasively in several locations of the body. …”
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