Drug repurposing: insights into the antimicrobial effects of AKBA against MRSA by Yingjia Li, Hongbing Ma

“…In addition, the effective antimicrobial effect was verified in vivo in a mouse model. And no detectable in vivo toxicity was found. …”
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The isolation and characterization of orbiviruses from ticks (ixodes uriae) by Spence, R

“…The viruses replicated in suckling mouse brain, chick embryo fibroblasts, Vero and BHK-21 cells, but not in Xenopus cells. …”

Automated whole-cell patch-clamp electrophysiology of neurons in vivo by Kodandaramaiah, Suhasa Bangalo, Talei Franzesi, Giovanni, Forest, Craig R., Chow, Brian Yichiun, Boyden, Edward

“…Whole-cell patch-clamp electrophysiology of neurons is a gold-standard technique for high-fidelity analysis of the biophysical mechanisms of neural computation and pathology, but it requires great skill to perform. We have developed a robot that automatically performs patch clamping in vivo, algorithmically detecting cells by analyzing the temporal sequence of electrode impedance changes. …”
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Cell-Membrane Biomimetic Indocyanine Green Liposomes for Phototheranostics of Echinococcosis by Xinxin Xiong, Jun Li, Duyang Gao, Zonghai Sheng, Hairong Zheng, Wenya Liu

“…In-vitro and in-vivo studies reveal that biomimetic Lipo-ICG with high biocompatibility can achieve in-vivo near-infrared fluorescence imaging and phototherapy of echinococcosis in mouse models. Our research is the first to apply bionanomaterials to the phototherapy of echinococcosis, which provides a new standard for the convenient and noninvasive detection and treatment of zoonotic diseases.…”
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Coumarin-Modified CQDs for Biomedical Applications—Two-Step Synthesis and Characterization by Łukasz Janus, Julia Radwan-Pragłowska, Marek Piątkowski, Dariusz Bogdał

“…Waste biomass such as lignin constitutes a great raw material for eco-friendly carbon quantum dots (CQDs) synthesis, which find numerous applications in various fields of industry and medicine. …”
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Facile assembly of upconversion nanoparticle-based micelles for active targeted dual-mode imaging in pancreatic cancer by Yong Han, Yanli An, Gang Jia, Xihui Wang, Chen He, Yinan Ding, Qiusha Tang

“…Furthermore, we successfully concluded that CD326-conjugated micelles endowed promising active targeting ability by conducting dual-mode imaging in human pancreatic cancer xenograft mouse model. Conclusions With good biocompatibility and excellent imaging properties of the micelles, our results uncover efficient active homing of those micelles after intravenous injection, and undoubtedly demonstrate the as-obtained micelles holds great potential for early pancreatic cancer diagnosis in the future and would pave the way for the following biomedical applications.…”
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Development of an electrooculogram (EOG) based virtual keyboard by Peh, Ruiliang

“…One of the work is using EOG signal to control a mouse cursor. Research has shown that EOG is better than EEG when it comes to man and machine interaction. …”
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CircRNA Expression Profile during Yak Adipocyte Differentiation and Screen Potential circRNAs for Adipocyte Differentiation by Yongfeng Zhang, Xian Guo, Jie Pei, Min Chu, Xuezhi Ding, Xiaoyun Wu, Chunnina Liang, Ping Yan

“…Furthermore, we analyzed the homology among yak, human and mouse circRNAs and found that 3536 yak circRNAs were homologous to human and mouse circRNAs. …”
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Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives by Nicolas Jacquelot, Cyril Seillet, Fernando Souza-Fonseca-Guimaraes, Adrian G. Sacher, Gabrielle T. Belz, Pamela S. Ohashi

“…In addition, they are equipped with a wide range of receptors, allowing them to detect “stressed cells’ such as cancer cells. Our understanding of the role of innate lymphoid cells in hepatocellular carcinoma (HCC) is growing owing to the development of mouse models, the progress in immunotherapeutic treatment and the recent use of scRNA sequencing analyses. …”
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Dynamics of 8G12 competitive antibody in “prime-boost” vaccination of Hepatitis E vaccine by Xing Wu, Pan Chen, Huijuan Lin, Yao Su, Xiaotian Hao, Yufeng Cao, Li Li, Fengcai Zhu, Zhenglun Liang

“…Total anti-HEV antibody has been used to reflect vaccine induced immune response in clinical trials for the lack of robust HEV neutralizing antibody detection methods. In this study, we applied a broad neutralizing mouse monoclonal antibody 8G12 to develop a competitive ELSIA assay and quantified 8G12 competitive antibody (8G12-like antibody) in serum samples. …”
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Assessing the spatiotemporal interactions of mesopredators in Sumatra’s tropical rainforest by Haidir, I, Macdonald, D, Linkie, M

“…Clouded leopard was more nocturnal and, consequently, had higher temporal overlap with the more nocturnal prey species, such as porcupine and mouse deer, whereas the more diurnal golden cat had higher overlap with the strictly diurnal great argus pheasant. …”

A new gene-scoring method for uncovering novel glaucoma-related genes using non-negative matrix factorization based on RNA-seq data by Xiaoqin Huang, Akhilesh K. Bajpai, Jian Sun, Fuyi Xu, Fuyi Xu, Lu Lu, Lu Lu, Siamak Yousefi, Siamak Yousefi

“…Findings showed our NMF method significantly improved the enrichment detection of glaucoma genes. The application of NMF with the scoring method showed great promise in the identification of marker genes for glaucoma.…”
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Characterization of the Human Papillomavirus 16 Oncogenes in K14HPV16 Mice: Sublineage A1 Drives Multi-Organ Carcinogenesis by Daniela Cochicho, Alexandra Nunes, João Paulo Gomes, Luís Martins, Mário Cunha, Beatriz Medeiros-Fonseca, Paula Oliveira, Margarida M. S. M. Bastos, Rui Medeiros, Joana Mendonça, Luis Vieira, Rui M. Gil da Costa, Ana Felix

“…This study aimed to determine the HPV16 variant and sublineage present in the K14HPV16 mouse model. This information can be considered of great importance to further enhance this K14HPV16 model as an essential research tool and optimize its use for basic and translational studies. …”
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Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma by Geng Wang, Hongmin Guo, Yan Ren, Weiyi Chen, Yixuan Wang, Jianing Li, Hua Liu, Jingjun Xing, Yanru Zhang, Na Li

“…Cell viability, migration, invasion, apoptosis, and DNA damage were detected by conventional methods. The rate-limiting proteins of the NER pathway were quantitated using PCR and Western blot. …”
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HEX expression and localization in normal mammary gland and breast carcinoma by Pandolfi Maura, Pestrin Marta, Manfioletti Guidalberto, Pellizzari Lucia, Puglisi Fabio, Puppin Cinzia, Piga Andrea, Di Loreto Carla, Damante Giuseppe

“…</p> <p>Results</p> <p>In normal breast HEX was detected both in the nucleus and in the cytoplasm. …”
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A Simple ICT-Based Fluorescent Probe for HOCl and Bioimaging Applications by Yan Zheng, Shuang Wu, Yifan Bing, Huimin Li, Xueqin Liu, Wenlan Li, Xiang Zou, Zhongyuan Qu

“…Expectantly, the fluoxetine-induced liver injury model is successfully established, and probe <b>1</b> has been used for detecting the fluctuation of ClO⁻ levels in the mouse model of fluoxetine-induced liver injury. …”
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Development and validation of a PCR-free nucleic acid testing method for RNA viruses based on linear molecular beacon probes by Fuyu Du, Weijie Zhang, Huimin Yao, Yuqiong Xia, Xianghan Zhang, Peng Yang, Pengbo Ning

“…Conclusions The proposed RNA virus probe could be used as a PCR-free, cost-effective, and rapid point-of-care (POC) diagnostic platform for target RNA virus detection, holding great potential for the convenient monitoring of different RNA viruses for early mass virus screening. …”
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Direct administration of mesenchymal stem cell‐derived mitochondria improves cardiac function after infarction via ameliorating endothelial senescence by Xiaoting Liang, Yuelin Zhang, Fang Lin, Mimi Li, Xin Li, Yu Chen, Jing Liu, Qingshu Meng, Xiaoxue Ma, Enhao Wang, Lu Wei, Zhiying He, Huimin Fan, Xiaohui Zhou, Yue Ding, Zhongmin Liu

“…Replacing injured mitochondria with healthy mitochondria to restore mitochondrial bioenergy in myocardium holds great promise for cardioprotection after infarction. …”
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Indocyanine Green and Arginine-Glycine-Aspartic Acid Complex Used in Intraoperative Visualization during Resection of Bladder Tumour by Li Peng, I. R. Kabirov, A. R. Kasinskaya, Jiaqi Wang, Wanhai Xu, E. K. Zhuk, R. A. Nuralieva

“…In the connection, it is proposed to use a highly sensitive bladder cancer detection method, which also detects residual tumours. …”
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Efficient Mining of Anticancer Peptides from Gut Metagenome by Yue Ma, Xiaolin Liu, Xuan Zhang, Ying Yu, Yujing Li, Moshi Song, Jun Wang

“…Moreover, the therapeutic potential of the two most promising peptides in a mouse xenograft cancer model is evaluated. Encouragingly, the peptides exhibit effective tumor inhibition without any detectable toxic effects. …”
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