Reassessment of SST4 Somatostatin Receptor Expression Using SST4-eGFP Knockin Mice and the Novel Rabbit Monoclonal Anti-Human SST4 Antibody 7H49L61 by Amelie Lupp, Blanca Ehms, Ralf Stumm, Johannes Göckeritz, Christian Mawrin, Stefan Schulz

“…We generated a knockin mouse model that expresses a carboxyl-terminal SST4-eGFP fusion protein. …”
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Therapeutic Effects of Lifei Decoction in a Murine Model of COPD Induced by LPS and Cigarette Smoke by Lu L, Zhu C, Xu J, Hu Y, Dai J, Wang S, Wei T

“…Therefore, the objective of this study was to investigate the therapeutic efficacy and underlying mechanism of LD in a mouse model of COPD induced by cigarette smoke (CS) combined with lipopolysaccharide (LPS).Methods: Hematoxylin-eosin (H&E) staining was employed to observe the pathological alterations in lung tissue, while ELISA was utilized for the detection of levels of inflammatory factors in both lung tissue and bronchoalveolar lavage fluid (BALF). …”
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Improving gene set analysis of microarray data by SAM-GS by Famulski Konrad S, Einecke Gunilla, Jhangri Gian S, Adewale Adeniyi J, Liu Qi, Mueller Thomas, Potter John D, Dinu Irina, Halloran Philip, Yasui Yutaka

“…</p> <p>Results</p> <p>Using a mouse microarray dataset with simulated gene sets, we illustrate that GSEA gives statistical significance to gene sets that have no gene associated with the phenotype (null gene sets), and has very low power to detect gene sets in which half the genes are moderately or strongly associated with the phenotype (truly-associated gene sets). …”
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The biocompatibility studies of polymer dots on pregnant mice and fetuses by Wu, Na, Zhang, Zheng, Zhou, Jie, Sun, Zezhou, Deng, Yueyue, Lin, Guimiao, Ying, Ming, Wang, Xiaomei, Yong, Ken-Tye, Wu, Changfeng, Xu, Gaixia

“…Levels of placenta growth related factors were detected by RT-PCR to evaluate the function of placenta. …”
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Targeting Peptide, Fluorescent Reagent Modified Magnetic Liposomes Coated with Rapamycin Target Early Atherosclerotic Plaque and Therapy by Chen Huang, Wentao Huang, Lifen Zhang, Chunyu Zhang, Chengqian Zhou, Wei Wei, Yongsheng Li, Quan Zhou, Wenli Chen, Yukuan Tang

“…Based on our results, the synthesized theragnostic Rap/Fe₃O₄@VHP-Lipo serves as a great label for both MRI and fluorescence bimodal imaging of atherosclerosis. …”
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Sustained and cost effective silver substrate for surface enhanced Raman spectroscopy based biosensing by Ju, Jian, Liu, Wei, Perlaki, Clint Michael, Chen, Keren, Feng, Chunhua, Liu, Quan

“…The Ag NP@N-GQD thin film in the dry state was then successfully applied as a SERS substrate for glucose detection in mouse blood samples. The new substrate was synthesized under mild experimental conditions, and the cost increase due to N-GQD was negligible. …”
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Microbiome and spatially resolved metabolomics analysis reveal the anticancer role of gut Akkermansia muciniphila by crosstalk with intratumoral microbiota and reprogramming tumora... by Zhuxian Zhu, Jixu Cai, Weiwei Hou, Ke Xu, Xuxiao Wu, Yuanlin Song, Chunxue Bai, Yin-Yuan Mo, Ziqiang Zhang

“…Of great interest, gavaged Akk may migrate into tumor tissue and influence the composition of intratumoral microbiome. …”
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Factors Influencing Quantification of in Vivo Bioluminescence Imaging: Application to Assessment of Pancreatic Islet Transplants by John Virostko, Zhongyi Chen, Michael Fowler, Greg Poffenberger, Alvin C. Powers, E. Duco Jansen

“…Detected luminescence decreased with increasing angle between the mouse surface normal and optical axis. …”
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Platycodin D2 enhances P21/CyclinA2-mediated senescence of HCC cells by regulating NIX-induced mitophagy by Lili Sun, Yaru Li, Renshuang Zhao, Qinlei Fan, Fei Liu, Yilong Zhu, Jicheng Han, Yunyun Liu, Ningyi Jin, Xiao Li, Yiquan Li

“…Methods First, the CCK8 assay was used to detect the inhibitory effect of PD2 on HCC cells. …”
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Polydopamine Modified Ceria Nanorods Alleviate Inflammation in Colitis by Scavenging ROS and Regulating Macrophage M2 Polarization by Zhang B, Li Q, Xu Q, Li B, Dong H, Mou Y

“…The ROS scavenging ability of CeO2@PP was detected by using flow cytometry and confocal laser scanning microscope (CLSM). …”
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Exploring the mutagenic consequences of inflammation and DNA damage by Kay, Jennifer Elizabeth, Ph. D. Massachusetts Institute of Technology

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Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway by Yirou Lei, Jiaying He, Fang Hu, Hao Zhu, Jing Gu, Lijuan Tang, Man Luo

“…Abstract Background Pulmonary rehabilitation training is of great significance for the prognosis of chronic obstructive pulmonary disease (COPD) patients. …”
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Genetic model of motor neuron disease in B6SJL-Tg mice: new data on the dynamics of motor symptoms and immunohistochemical manifestations of the neurodegenerative process by А. V. Stavrovskaya, D. N. Voronkov, E. A. Artyomova, B. V. Belugin, М. М. Shmarov, N. G. Yamshchikova, А. S. Gushchina, А. S. Olshansky, B. S. Naroditskiy, S. N. Illarioshkin

“…The B6SJL-Tg (SOD1*G93A) mouse strain expresses a mutant form of human superoxide dismutase 1. …”
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Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage by Shukun Wan, Xiaoqing Wang, Weina Chen, Manli Wang, Jingsong Zhao, Zhongyan Xu, Rong Wang, Chenyang Mi, Zhaodian Zheng, Huidong Zhang

“…Miscarriage (abnormal early embryo loss), accounting for 15-25% pregnant women worldwide, greatly harms human reproduction. However, the adverse effects of NPs on miscarriage have never been explored. …”
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In vivo gene transfer by electroporation allows expression of a fluorescent transgene in hamster testis and epididymal sperm and has no adverse effects upon testicular integrity or... by Hibbitt, O, Coward, K, Kubota, H, Prathalingham, N, Holt, W, Kohri, K, Parrington, J

“…The study of gene function in testis and sperm has been greatly assisted by transgenic mouse models. Recently, an alternative way of expressing transgenes in mouse testis has been developed that uses electroporation to introduce transgenes into the male germ cells. …”

Antibacterial activity of the antimicrobial peptide PMAP-36 in combination with tetracycline against porcine extraintestinal pathogenic Escherichia coli in vitro and in vivo by Qi Tao, Yi Lu, Qian Liu, Runqiu Chen, Yating Xu, Gang Li, Xiaoxiang Hu, Chao Ye, Lianci Peng, Rendong Fang

“…Abstract The increase in the emergence of antimicrobial resistance has led to great challenges in controlling porcine extraintestinal pathogenic Escherichia coli (ExPEC) infections. …”
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LncRNA‐SNHG15 enhances cell proliferation in colorectal cancer by inhibiting miR‐338‐3p by Min Li, Zehua Bian, Guoying Jin, Jia Zhang, Surui Yao, Yuyang Feng, Xue Wang, Yuan Yin, Bojian Fei, Qingjun You, Zhaohui Huang

“…Abstract The incidence and death rate of colorectal cancer (CRC) is very high, which brings great need to understand the early molecular events of CRC. …”
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A modified and tailored human follicle isolation procedure improves follicle recovery and survival by Maria Costanza Chiti, Marie-Madeleine Dolmans, Maria Hobeika, Alice Cernogoraz, Jacques Donnez, Christiani Andrade Amorim

“…Moreover, improved follicle survival inside an artificial ovary prototype was detected after one week of xenografting.…”
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Comprehensive profiling of stem-like features in pediatric glioma cell cultures and their relation to the subventricular zone by Marc-Antoine Da-Veiga, Natacha Coppieters, Arnaud Lombard, Bernard Rogister, Virginie Neirinckx, Caroline Piette

“…Four cultures displaying distinctive stem-like profiles were further tested for their ability to initiate tumors and invade the brain tissue in mouse orthotopic xenografts. The selected cell cultures all showed a great tumor formation capacity, but only DMG H3-K27 altered cells demonstrated a highly infiltrative phenotype. …”
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Microneedle technology on dermatological application by Ning, Xiaoyu

“…Over the past decades, great achievements have been made on the optimization of the MNs’ fabrication techniques, expending the various features of the MNs and generation of the MNs with multiple functions. …”
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