-
161
Investigating the effect of melanopsin gene therapy in the degenerate retina
Published 2015“…Therefore with further development, this optogenetic strategy has great potential for the treatment of patients with end-stage retinal degeneration.…”
Thesis -
162
-
163
Beneficial effect of skin micro-needling in the treatment of alopecia areata and its clinical assessment
Published 2021-03-01“…Moreover, the dorsal hair of C57BL/6 mouse was removed and then divided into model group, minoxidil group and micro-needling group. …”
Get full text
Article -
164
Ethyl acetate extract of Terminalia chebula alleviates DSS-induced ulcerative colitis in C57BL/6 mice
Published 2023-12-01“…Disease progression was assessed by monitoring the mouse’s weight change and disease activity index (DAI). …”
Get full text
Article -
165
Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer’s disease...
Published 2024-02-01“…The neurons loss, cholinergic function, inflammation responses, biological barrier function in the mouse brain and intestinal tissues were evaluated through a variety of techniques, and the gut microbiota was detected using 16SrRNA sequencing. …”
Get full text
Article -
166
Characterization and efficacy against carbapenem-resistant Acinetobacter baumannii of a novel Friunavirus phage from sewage
Published 2024-04-01“…Moreover, after day 3 post-infection, phage Ab_WF01 reduced inflammatory response, with strongly ameliorated histological damage and bacterial clearance in infected tissue organs (lungs, liver, and spleen) in mouse CRAB infection model. Taken together, these results show that phage Ab_WF01 holds great promise as a potential alternative agent with excellent stability for against CRAB infections.…”
Get full text
Article -
167
Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models
Published 2023-12-01“…As such, there has been a great deal of research into clinical strategies for the disease, including diagnostic biomarkers and possible strategies for treatment and prevention. …”
Get full text
Article -
168
Long noncoding RNA TINCR facilitates hepatocellular carcinoma progression and dampens chemosensitivity to oxaliplatin by regulating the miR-195-3p/ST6GAL1/NF-κB pathway
Published 2022-01-01“…In-depth study of specific regulatory mechanisms is of great value in providing potential therapeutic targets. …”
Get full text
Article -
169
The serum levels of activin A and bone morphogenetic protein-4 and -6 in patients with fibrodysplasia ossificans progressiva
Published 2023-05-01“…Abstract Background Fibrodysplasia ossificans progressiva (FOP) is an ultrarare and disabling genetic disorder of connective tissue characterized by congenital malformation of the great toes, and progressive heterotopic ossification (HO) in soft connective tissues. …”
Get full text
Article -
170
Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists
Published 2023-07-01“…Surprisingly, the BECC470s molecule, unlike the others, displayed a nearly baseline signal when monitored using a Limulus amebocyte lysate (LAL) endotoxin detection system. Despite this, it was shown to behave as an agonist for human and mouse TLR4 when tested using multiple cell-based systems. …”
Get full text
Article -
171
Using a Prime-Boost Vaccination Strategy That Proved Effective for High Resolution Epitope Mapping to Characterize the Elusive Immunogenicity of Survivin
Published 2021-12-01“…However, the vaccination method shows great promise as a strategy for identifying novel and subdominant T cell epitopes.…”
Get full text
Article -
172
Exogenous iron impairs the anti-cancer effect of ascorbic acid both in vitro and in vivo
Published 2023-04-01“…The association between iron and AA has attracted great attention but was still controversial due to the complicated roles of iron in tumors. …”
Get full text
Article -
173
Influence of FOSL1 Inhibition on Vascular Calcification and ROS Generation through Ferroptosis via P53-SLC7A11 Axis
Published 2023-02-01“…Conclusions: In this study, we observed a significant protective effect when we reduced the expression of FOSL1 during vascular calcification, and this effect might regulate ferroptosis to a great extent.…”
Get full text
Article -
174
No safe renal warm ischemia time—The molecular network characteristics and pathological features of mild to severe ischemia reperfusion kidney injury
Published 2022-11-01“…We established varying degrees of renal injury due to different ischemia time (0 min, 16 min, 18 min, 20 min, 22 min, 24 min, 26 min, 28 min, and 30 min) on unilateral (left kidney) ischemia-reperfusion injury and contralateral (right kidney) resection (uIRIx) mouse model. Mice were sacrificed 24 h after uIRIx, blood samples were harvested to detect serum creatinine (Scr), and kidney tissue samples were harvested to perform Periodic Acid-Schiff (PAS) staining and RNA-Seq. …”
Get full text
Article -
175
Long-term simulated microgravity alters gut microbiota and metabolome in mice
Published 2023-03-01“…After 8 weeks of SMG, alterations of the intestinal microbiota and metabolites were detected using 16S rRNA sequencing and untargeted metabolomics. …”
Get full text
Article -
176
Reporter Coxsackievirus A5 Expressing iLOV Fluorescent Protein or Luciferase Used for Rapid Neutralizing Assay in Cells and Living Imaging in Mice
Published 2023-09-01“…Living imaging was performed on mice with CV-A5-Nluc, which exhibited specific bioluminescence in virus-disseminated organs, while fluorescence induced by CV-A5-iLOV was weakly detected. The reporter-gene-tagged CV-A5 can be used to study the infection and mechanisms of CV-A5 pathogenicity in a mouse model. …”
Get full text
Article -
177
Circulating tRNA-Derived Small RNAs as Novel Radiation Biomarkers of Heavy Ion, Proton and X-ray Exposure
Published 2021-12-01“…Moreover, the radiation responses of these 5 serum tsRNAs were reproduced in other mouse strains, and the sequences of them could be detected in serum of humans. …”
Get full text
Article -
178
A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
Published 2024-02-01“…Using this method, we detect 8,789 bivalent regions in mouse embryonic stem cells corresponding to 3,918 predominantly CpG rich and developmentally regulated gene promoters. …”
Get full text
Article -
179
Implication of 99mTc-sum IL-2 SPECT/CT in immunotherapy by imaging of tumor-infiltrating T cells
Published 2023-03-01“…SPECT/CT imaging and biodistribution studies of 99mTc-sum IL-2 were performed in a MC38 mouse model. Wild type IL-2 (IL-2) was used as control in the above studies. …”
Get full text
Article -
180
An Innovative Model of ISS‐Based Multiple Fractures and Gastrointestinal Dysfunction Related to c‐Kit Protein Expression on Interstitial Cells of Cajal
Published 2023-05-01“…Here we describe a newly developed mouse model of postoperative gastrointestinal dysfunction after multiple fractures. …”
Get full text
Article