Investigating the effect of melanopsin gene therapy in the degenerate retina by De Silva, S

“…Therefore with further development, this optogenetic strategy has great potential for the treatment of patients with end-stage retinal degeneration.…”

Proteomics for cancer biomarker discovery by Volchenboum, Samuel Louis

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Beneficial effect of skin micro-needling in the treatment of alopecia areata and its clinical assessment by PENG Ya-wen, LEI Tie-chi

“…Moreover, the dorsal hair of C57BL/6 mouse was removed and then divided into model group, minoxidil group and micro-needling group. …”
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Ethyl acetate extract of Terminalia chebula alleviates DSS-induced ulcerative colitis in C57BL/6 mice by Wan-Rong Dong, Yao-Yao Li, Tian-Tian Liu, Gao Zhou, Yu-Xin Chen

“…Disease progression was assessed by monitoring the mouse’s weight change and disease activity index (DAI). …”
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Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer’s disease... by Haojie Ni, Muqiu Liu, Mindie Cao, Lingyu Zhang, Yijing Zhao, Lang Yi, Yanwu Li, Liang Liu, Peixun Wang, Qun Du, Hua Zhou, Yan Dong

“…The neurons loss, cholinergic function, inflammation responses, biological barrier function in the mouse brain and intestinal tissues were evaluated through a variety of techniques, and the gut microbiota was detected using 16SrRNA sequencing. …”
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Characterization and efficacy against carbapenem-resistant Acinetobacter baumannii of a novel Friunavirus phage from sewage by Zhitao Wang, Xue Yang, Hui Wang, Shuxian Wang, Ren Fang, Xiaotian Li, Jiayin Xing, Qianqian Wu, Zhaoli Li, Ningning Song

“…Moreover, after day 3 post-infection, phage Ab_WF01 reduced inflammatory response, with strongly ameliorated histological damage and bacterial clearance in infected tissue organs (lungs, liver, and spleen) in mouse CRAB infection model. Taken together, these results show that phage Ab_WF01 holds great promise as a potential alternative agent with excellent stability for against CRAB infections.…”
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Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models by Shun Xiong, Zhaoping Liu, Xiaohong Zhang, Shaobin Huang, Xuan Ding, Jie Zhou, Jiangchen Yao, Weiwei Li, Shuangquan Liu, Feijun Zhao

“…As such, there has been a great deal of research into clinical strategies for the disease, including diagnostic biomarkers and possible strategies for treatment and prevention. …”
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Long noncoding RNA TINCR facilitates hepatocellular carcinoma progression and dampens chemosensitivity to oxaliplatin by regulating the miR-195-3p/ST6GAL1/NF-κB pathway by Jie Mei, Wenping Lin, Shaohua Li, Yuhao Tang, Zhiwei Ye, Lianghe Lu, Yuhua Wen, Anna Kan, Jingwen Zou, Chengyou Yu, Wei Wei, Rongping Guo

“…In-depth study of specific regulatory mechanisms is of great value in providing potential therapeutic targets. …”
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The serum levels of activin A and bone morphogenetic protein-4 and -6 in patients with fibrodysplasia ossificans progressiva by Zhengqin Ye, Siyi Wang, Chang Shan, Qi Zhu, Ying Xue, Keqin Zhang

“…Abstract Background Fibrodysplasia ossificans progressiva (FOP) is an ultrarare and disabling genetic disorder of connective tissue characterized by congenital malformation of the great toes, and progressive heterotopic ossification (HO) in soft connective tissues. …”
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Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists by Gang Hu, David J. Varisco, Sayan Das, C. Russell Middaugh, Francesca Gardner, Robert K. Ernst, Wendy L. Picking, William D. Picking

“…Surprisingly, the BECC470s molecule, unlike the others, displayed a nearly baseline signal when monitored using a Limulus amebocyte lysate (LAL) endotoxin detection system. Despite this, it was shown to behave as an agonist for human and mouse TLR4 when tested using multiple cell-based systems. …”
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Using a Prime-Boost Vaccination Strategy That Proved Effective for High Resolution Epitope Mapping to Characterize the Elusive Immunogenicity of Survivin by Robert C. Mould, Jacob P. van Vloten, Amanda W. K. AuYeung, Scott R. Walsh, Jondavid de Jong, Leonardo Susta, Anthony J. Mutsaers, James J. Petrik, Geoffrey A. Wood, Sarah K. Wootton, Khalil Karimi, Byram W. Bridle

“…However, the vaccination method shows great promise as a strategy for identifying novel and subdominant T cell epitopes.…”
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Exogenous iron impairs the anti-cancer effect of ascorbic acid both in vitro and in vivo by Bingling Zhong, Lin Zhao, Jie Yu, Ying Hou, Nana Ai, Jin-Jian Lu, Wei Ge, Xiuping Chen

“…The association between iron and AA has attracted great attention but was still controversial due to the complicated roles of iron in tumors. …”
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Influence of FOSL1 Inhibition on Vascular Calcification and ROS Generation through Ferroptosis via P53-SLC7A11 Axis by Sisi Shao, Yaoxin Liu, Wanzi Hong, Yuanxi Mo, Fen Shu, Lei Jiang, Ning Tan

“…Conclusions: In this study, we observed a significant protective effect when we reduced the expression of FOSL1 during vascular calcification, and this effect might regulate ferroptosis to a great extent.…”
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No safe renal warm ischemia time—The molecular network characteristics and pathological features of mild to severe ischemia reperfusion kidney injury by Ya-Lei Chen, Huai-Kang Li, Lei Wang, Jian-Wen Chen, Jian-Wen Chen, Xin Ma

“…We established varying degrees of renal injury due to different ischemia time (0 min, 16 min, 18 min, 20 min, 22 min, 24 min, 26 min, 28 min, and 30 min) on unilateral (left kidney) ischemia-reperfusion injury and contralateral (right kidney) resection (uIRIx) mouse model. Mice were sacrificed 24 h after uIRIx, blood samples were harvested to detect serum creatinine (Scr), and kidney tissue samples were harvested to perform Periodic Acid-Schiff (PAS) staining and RNA-Seq. …”
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Long-term simulated microgravity alters gut microbiota and metabolome in mice by Lu Yuan, Rong Zhang, Xinlou Li, Caiyun Gao, Xiangnan Hu, Safdar Hussain, Linlin Zhang, Moye Wang, Xiaoyu Ma, Qiuxia Pan, Xiaotong Lou, Shaoyan Si

“…After 8 weeks of SMG, alterations of the intestinal microbiota and metabolites were detected using 16S rRNA sequencing and untargeted metabolomics. …”
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Reporter Coxsackievirus A5 Expressing iLOV Fluorescent Protein or Luciferase Used for Rapid Neutralizing Assay in Cells and Living Imaging in Mice by Wei-Ping Jin, Chen Wang, Jie Wu, Jing Guo, Sheng-Li Meng, Ze-Jun Wang, Dai-Guan Yu, Shuo Shen

“…Living imaging was performed on mice with CV-A5-Nluc, which exhibited specific bioluminescence in virus-disseminated organs, while fluorescence induced by CV-A5-iLOV was weakly detected. The reporter-gene-tagged CV-A5 can be used to study the infection and mechanisms of CV-A5 pathogenicity in a mouse model. …”
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Circulating tRNA-Derived Small RNAs as Novel Radiation Biomarkers of Heavy Ion, Proton and X-ray Exposure by Wenjun Wei, Hao Bai, Yaxiong Chen, Tongshan Zhang, Yanan Zhang, Junrui Hua, Jinpeng He, Nan Ding, Heng Zhou, Jufang Wang

“…Moreover, the radiation responses of these 5 serum tsRNAs were reproduced in other mouse strains, and the sequences of them could be detected in serum of humans. …”
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A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin by Janith A. Seneviratne, William W. H. Ho, Eleanor Glancy, Melanie A. Eckersley-Maslin

“…Using this method, we detect 8,789 bivalent regions in mouse embryonic stem cells corresponding to 3,918 predominantly CpG rich and developmentally regulated gene promoters. …”
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Implication of 99mTc-sum IL-2 SPECT/CT in immunotherapy by imaging of tumor-infiltrating T cells by Fan Wang, Hannan Gao, Jiyun Shi, Yue Yu, Qi Luo, Yu Gao, Zhichen Sun, Yining Sun, Xiaotu Ma, Chuanhui Han

“…SPECT/CT imaging and biodistribution studies of 99mTc-sum IL-2 were performed in a MC38 mouse model. Wild type IL-2 (IL-2) was used as control in the above studies. …”
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An Innovative Model of ISS‐Based Multiple Fractures and Gastrointestinal Dysfunction Related to c‐Kit Protein Expression on Interstitial Cells of Cajal by Shi‐Jie Meng, Meng‐Qiang Fan, Jian‐Sheng Qian, Jing‐Wen Zhang, Hui‐Hui Xu, Yang Zheng, Wei‐Qiang Zhao, Le‐Tian Shan, Jie‐Feng Huang

“…Here we describe a newly developed mouse model of postoperative gastrointestinal dysfunction after multiple fractures. …”
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