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441
Optimizing the enzymatic release of MMAE from isoDGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker
Published 2023-07-01“…Antibody-Drug Conjugates (ADCs) and Small Molecule-Drug Conjugates (SMDCs) represent successful examples of targeted drug-delivery technologies for overcoming unwanted side effects of conventional chemotherapy in cancer treatment. In both strategies, a cytotoxic payload is connected to the tumor homing moiety through a linker that releases the drug inside or in proximity of the tumor cell, and that represents a key component for the final therapeutic effect of the conjugate. …”
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442
Naïve Theories of Emotions: Why People Might (Not) Be Uncertain or in Conflict About Felt Emotions
Published 2023-05-01“…Each participant (N = 1,156) judged a typical antecedent for a single emotion—e.g., Jealousy: story protagonist SP sees his or her partner kiss someone. The Yes/No results showed that SP was frequently expected to experience both phenomena, the more so the greater the event impact (Yes range: 40–86%). …”
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443
A Systematic Review on Oral Health Care Programs for the Elderly in Korea (2009∼2020)
Published 2021-12-01“…As for the type of intervention, 14 studies that conducted both theory and practice were the most frequent. …”
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444
Body image alteration in women with breast cancer: A concept analysis using an evolutionary method
Published 2023-05-01“…Conclusions: This study provides comprehensive conceptualizations that encompass individual, interpersonal, and sociocultural components and cover both negative and positive changes in body image from a long-term perspective. …”
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445
Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats
Published 2021-10-01“…The unilateral administration of NKB or vehicle in the close vicinity of KNDy neurons under simultaneous MUA recording from both sides revealed that only NKB evoked MUA volley(s) immediately after administration. …”
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446
#363 : Kisspeptins and Human Reproduction: New Challenges in the Management of Couple Infertility
Published 2023-12-01“…Kisspeptin is involved in oocyte development, quality of semen, steroidogenesis in both the ovaries and testes, sexual desires and pregnancy. …”
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447
Prevalence of intestinal helminths of household dogs and cats and perception of related zoonoses by owners in Ipoh, Perak, Malaysia
Published 2015“…The overall prevalence of parasitism in both dogs and cats was 38%. Risk calculation revealed that prevalence of parasitism especially toxocariasis was significantly (p<0.05) higher in the less than 6-months age group. …”
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448
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449
An integrative literature review of kidney transplantation knowledge tools
Published 2023-01-01“…Of these, seven studies (46.7%) targeted KT patients, five (33.3%) targeted KT candidates, and three (20.0%) included both groups. The number of items in the tools ranged from five to 33 items. …”
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450
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Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats.
Published 2015-01-01Get full text
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453
New data on pathotype distribution and mefenoxam tolerance of Plasmopara halstedii in Hungary
Published 2021-03-01Get full text
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454
Why does the zebrafish cloche mutant develop lens cataract?
Published 2019-01-01Get full text
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455
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Bias caused by water adsorption in hourly PM measurements
Published 2017-07-01Get full text
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457
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458
Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates
Published 2023-04-01Get full text
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459
Modulation of auxin and cytokinin responses by early steps of the phenylpropanoid pathway
Published 2018-11-01“…This auxin/phenylpropanoid interaction impacts both shoot and root development and revealed an auxin-dependent stimulatory effect of trans-cinnamic acid feeding on leaf expansion and thus biomass accumulation. …”
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460