The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01 E by Ali, MS, Stockdale, L, Sagara, I, Zongo, I, Yerbanga, RS, Mahamar, A, Nikièma, F, Tapily, A, Sompougdou, F, Diarra, M, Bellamy, D, Provstgaard-Morys, S, Zoungrana, C, Issiaka, D, Haro, A, Sanogo, K, Sienou, AA, Kaya, M, Traore, S, Dicko, OM, Kone, Y, Yalcouye, H, Thera, I, Diarra, K

“…In many malaria-endemic areas of Africa, the burden of malaria is largely restricted to the rainy season and, therefore, a recent trial conducted in Burkina Faso and Mali explored the impact of repeated annual booster doses of RTS,S/AS01E given immediately prior to the malaria transmission season until children reached the age of five years. …”

Health economic aspects of childhood excess weight by Onyimadu, O

“…Despite the increasing public health burden, substantial uncertainty persists regarding key economic parameters and outcomes necessary to guide research and inform policy for the efficient allocation of resources that target childhood excess weight.…”

Adverse events of common psychiatric medications: an umbrella review by Bartellas, K

“…The purpose of this thesis is to systematically review the scientific literature to estimate the prevalence and burden of adverse events among the most common psychiatric medications.…”

Pilot study of a ketogenic diet in bipolar disorder: a process evaluation by P. Rigby, B, Needham, N, Grossi, H, Kamenska, I, H. Campbell, I, Meadowcroft, B, Creasy, F, Fisher, C, Bahuguna, P, Norrie, J, Thompson, G, C. Gibbs, M, Mitchell-Grigorjeva, M, McLellan, A, Moses, T, Burgess, K, Brown, R, J. Thrippleton, M, Campbell, H, J. Smith, D, A. Simpson, S

“…Results: Five themes were identified in the qualitative data: (1) ‘Encouraging entry and supporting exit’ (e.g. recognising and managing participants’ varied motives and expectations, including around weight loss and symptom alleviation); (2) ‘Challenging but potentially transformational,’ which reflects that while it can be difficult to initiate and maintain a ketogenic diet day-to-day, many participants perceived physical and psychological benefits (e.g. significant weight loss, mood stability and enhanced ability to focus); (3) ‘Intervention facilitators,’ including a range of behavioural (e.g. goal setting), social (e.g. family and dietitians) and technological (e.g. apps for monitoring) support mechanisms; (4) ‘Intervention barriers’ (e.g. dietary preferences, concerns about the diet and its impact, the testing burden and capacity of the delivery team); and (5) ‘The wider context’ (e.g. the cost of living and sociocultural expectations) was a crucial factor explaining differential experiences. …”

Mechanistic insights on protein aggregation and phase separation by Casablancas Antràs, V

“…The pathological aggregation of proteins into amyloid fibrils and other morphologies of aggregates is a hallmark of several human diseases, many of which are neurodegenerative disorders like Alzheimer’s and Parkinson’s and pose a global health burden due the limited therapeutic approaches.</p> <br> <p>Proteins carry out their function not only in very well defined structured states, which is the basis of the structure-function dogma, but also by exploiting the unique properties of conformationally heterogeneous disordered states. …”

Translation, adaptation and validation of an epilepsy screening instrument in two Ghanaian languages by Darkwa, EK, Asiamah, S, Awini, E, Sottie, C, Godi, A, Williams, JE, Akpalu, A, Cross, JH, Sander, JW, Sen, A, Newton, CR, Danso-Appiah, A, Adjei, P

“…More community-based studies are required to understand better the actual burden of epilepsy in these areas and the difficulties in accessing healthcare. …”

Long-term fine particulate matter exposure on lung cancer incidence and mortality in Chinese nonsmokers by Chen, Z, Meng, X, Han, Y, Mou, Y, Ji, C, Zhu, X, Yu, C, Sun, D, Yang, L, Sun, Q, Chen, Y, Du, H, Dai, J, Hu, Z, Lv, J, Jin, G, Ma, H, Kan, H, Li, L, Shen, H

“…Strengthening air pollution control measures in China has the potential to significantly reduce the burden of LCINS.</p> …”

Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…In each regime, we determine the biological processes that may underpin positive and negative treatment outcomes and assess which treatment (RT, HT or RT + HT) and dosing regimen maximise the reduction in tumour burden. This work enables us to generate a set of hypotheses that may explain some of the widely varying tumour behaviours observed experimentally and clinically.…”

Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I by Liu, X, Zhang, Z, Aguirre, T, Shipton, ML, Fu, L, Du, J, Furkert, D, Qi, J, Chin, AC, Riley, AM, Liu, T, Zhang, X, Potter, BVL, Fiedler, D, Zhu, Y, Fu, C

“…Hepatocyte-specific deletion of IP6K1 elevates circulating apoA-I levels, which augments cholesterol efflux and lowers the burden of atherosclerosis. Mice with both&nbsp;<em>apoA-I</em>&nbsp;KO and hepatocyte-specific&nbsp;<em>IP6K1</em>&nbsp;KO were generated to validate that IP6K1 deletion-induced atheroprotection requires apoA-I.…”

The mediating role of health literacy between the presence of chronic disease and psychological distress among older persons in Xian City of China by Guo, Kun, Ouyang, Jing, Minhat, Halimatus Sakdiah

“…Background: The increased number of older persons in China, and the prevalence of most chronic diseases raised with age significantly increased the total disease burden. When a person ages, psychological distress happens when they are faced with stressors that they cannot cope with. …”
Get full text

The last flower: transforming inner feelings into innovative solutions by Yeo, Jesvin Puay-Hwa

“…The design brief was inspired by an example from Paul Arden’s book, Documenting a Flower – The Last Flower. …”
Get full text
Get full text

Towards depth-resolved multi-cubic-centimeter field of view endoscopic camera for intraoperative nerve identification. by Yoon, Yong-Chul

“…However, fluorescence imaging has several limitations, including a disrupted workflow (due to the need for specialized lighting) and a significant regulatory burden. For these reasons, fluorescence-based nerve visualization has not yet been clinically adopted. …”
Get full text

Genomic insights into Vibrio cholerae O1 responsible for cholera epidemics in Tanzania between 1993 and 2017 by Hounmanou, Yaovi Mahuton Gildas, Leekitcharoenphon, Pimlapas, Kudirkiene, Egle, Mdegela, Robinson H., Hendriksen, Rene S., Olsen, John Elmerdahl, Dalsgaard, Anders

“…Background: Tanzania is one of seven countries with the highest disease burden caused by cholera in Africa. We studied the evolution of Vibrio cholerae O1 isolated in Tanzania during the past three decades. …”
Get full text

Robust congestion management and service restoration for active distribution networks by Shen,Feifan

“…Most of the existing service restoration models are solved by centralized algorithms based on centralized infrastructure, which is faced with a few drawbacks regarding the computation burden, single-point failure risk, and privacy information protection. …”
Get full text

Reinforcement learning for robot assembly by Vuong Quoc Nghia

“…Learning approaches will become prominent in this context since learning shifts the burden from humans to the robot. Instead of attempting to obtain an accurate model of the surrounding environments or to program the controller, the robot can acquire a dynamics model or directly learn optimal control policies from experience. …”
Get full text

Formulation and in-vitro release study of drug loaded liposomes for treating dry eye disease by Chua, Yan Ni

“…Dry eye disease is regarded as an economic burden as the patients incurred financial loss during the treatment of DED. …”
Get full text

Performance of epoxy-based self-healing mortar by Ariffin, Nur Farhayu

Get full text

Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection by Spatola, M, Nziza, N, Irvine, EB, Cizmeci, D, Jung, W, Van, LH, Nhat, LTH, Ha, VTN, Phu, NH, Nghia, HDT, Thwaites, GE, Lauffenburger, DA, Fortune, S, Thuong, NTT, Alter, G

“…<i>Mycobacterium tuberculosis</i>, the causative agent of tuberculosis (TB), remains a global health burden. While <i>M. tuberculosis</i> is primarily a respiratory pathogen, it can spread to other organs, including the brain and meninges, causing TB meningitis (TBM). …”

Infection patterns of scabies and tinea between inland and resettled indigenous Negrito communities in peninsular Malaysia by Er, Yi Xian, Than, Leslie Thian Lung, Muslim, Azdayanti, Yap, Nan Jiun, Tee, Mian Zi, Abdull-Majid, Nurmanisha, Lee, Soo Ching, Shahrizal, Shezryna, Lim, Yvonne Ai Lian

“…Skin infections cause significant health burden and affect underserved communities such as the indigenous Negrito communities disproportionately. …”
Get full text

Environmental and social assessments of an Island Marine Park in Malaysia by Mohd Noor, Mohd Iqbal

“…The conflict between tourism development and environmental sustainability in Malaysia Marine Parks is getting complicated when some tourism stakeholders believe that the governing policy of the parks are not tailored for their demands to achieve competitive advantage and this might burden the management of protected areas. This problem is addressed by applying three essays that cover three objectives. …”
Get full text