Understanding tumor cell plasticity in spatial transcriptomics with graph attention networks and walk-based pseudotime analysis by Zamora, Izabella

“…By estimating a differentiation path from epithelial to mesenchymal-like cells, we can identify intermediate states despite a limited set of tumor marker genes. This cellular differentiation path shows enrichment and depletion of certain cell types within local neighborhoods aligning with known correlations, and by leveraging inferred ligand-receptor interactions, we can pinpoint potential drivers of plasticity to test in vitro. …”
Get full text

Enhancing E. coli tolerance towards oxidative stress via engineering its global regulator cAMP Receptor Protein (CRP) by Basak, Souvik, Jiang, Rongrong

“…Classical strain engineering approaches are usually both time-consuming and labor intensive. Here, we aim to improve E. coli performance under oxidative stress via engineering its global regulator cAMP receptor protein (CRP), which can directly or indirectly regulate redox-sensing regulators SoxR and OxyR, and other ~400 genes in E. coli. …”
Get full text
Get full text

Cadmium isotope fractionation during adsorption onto calcite by Peng, H, Liu, P, Zheng, H, Belshaw, NS, Hu, S, Zhu, Z

“…Notably, αsorbed-aqueous = 0.99984, a reduced but resolvably lower value fractionation, was observed in the presence of PO43− which may be an important factor to be considered when interpreting Cd isotope signatures in nature. The enrichment of lighter Cd isotopes may result from highly distorted octahedral Cdsingle bondO6 sites of inner-sphere Cd complexes on calcite, indicated by extended X-ray absorption fine structure (EXAFS). …”

Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Marques, IF, Domènech-Panicello, C, Geurtsen, ML, Hoang, TT, Richmond, R, Polinski, K, Sirignano, L, Page, CM, Binter, A, Everson, T, Burt, A, Deuschle, M, Gilles, M, Streit, F, Mumford, SL, Magnus, P, Reiss, IKM, Vermeulen, MJ, Witt, SH, Chaves, I, Yeung, E, London, SJ, Guxens, M, Felix, JF

“…In a mouse model of prenatal jet lag exposure, information on offspring DNA methylation of ten homologous genes annotated to the 16 CpGs with P < 1 × 10−5 in our analysis was available, of which eight were associated (enrichment P: 1.62 × 10−11). …”

Estrogenic post-menopausal anti-osteoporotic mechanism of Achyranthes aspera L.: Phytochemicals and network pharmacology approaches by Huq, AKM Moyeenul, Stanslas, Johnson, Nizhum, Nisarat, Uddin, Md. Nazim, Maulidiani, Maulidiani, Roney, Miah, Abas, Faridah, Jamal, Jamia Azdina

“…Through network pharmacology, the potential effects, and mechanisms of these compounds in osteoporosis were revealed. About 55 target genes were linked to osteoporosis. GO and KEGG enrichment suggest regulation of female reproductive hormone related signaling pathways, which are also associated with estrogen dependent osteoporosis. …”
Get full text

DNA extraction methodologies for ultra long nanopore sequencing to determine chromosome specific rodent telomere lengths by Kidd, Elliot, Mooruth, Ravi, Meimaridou, Eirini, Walley, Andrew, Fairbrother, Una

“…Telomeres are involved in gene expression through Telomere Position Effect Over Long Distance (TPE-OLD) and indirectly through telomeric repeat containing RNA (TERRA). …”
Get full text

Neural abstractive summarization: improvements at the sequence-level by Ravaut, Mathieu

“…With enough data, pre-trained Transformer-based sequence-to-sequence models can be fine-tuned and achieve strong performance on abstractive summarization benchmarks. …”
Get full text

Distilling crowd knowledge from software-specific Q&A discussions for assisting developers’ knowledge search by Chen, Chunyang

“…I first build a basic software-specific knowledge graph including thousands of software-engineering terms and their associations by association rule mining and community detection. Then, I enrich the knowledge graph with more fine-grained relationships i.e., analogy among different third-party libraries. …”
Get full text

p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice by Vernì, Fiammetta, Saggio, Isabella, Burla, Romina, La Torre, Mattia, Zanetti, Giorgia, Bastianelli, Alex, Merigliano, Chiara, Del Giudice, Simona, Vercelli, Alessandro, Di Cunto, Ferdinando, Boido, Marina

“…Mutant mice were produced by reducing the expression of the gene Ft1 (AKTIP in humans). In vitro, AKTIP/Ft1 depletion causes telomere aberrations, DNA damage, and cell senescence. …”
Get full text
Get full text

A standardised fraction 1 (SF1) from clinacanthus nutans attenuates the stemness of cervical cancer stem-like cells via inhibition of notch1 signalling by Ismail, Faridah

“…Bioassay guided fractionation was employed for the isolation of SF1 from C. nutans leaf extract. The SiHa cell line was used for the enrichment of CCSCs by culturing the cells in CSC-conditioned medium (cervospheres). …”
Get full text

探 = In search of harmony by Ng, Woon Lam

“…Back in the days when I was learning the classical oil painting approach in New York Academy of Fine Art, I discovered the similarity in the painting techniques between watercolor and oil painting. …”
Get full text

Building occupant sensing : occupancy prediction and behavior recognition by Zhu, Qingchang

“…Occupancy levels are the coarse information, but occupants’ behaviors are the fine- grained ones. The occupant behavior recognition problem is further divided into simple motion-related activity recognition with inertial measurements and energy- related sound event recognition. …”
Get full text
Get full text

Dna markers and mapping of quantitative trait loci for yield and bunch quality in Deli dura X Yangambi pisifera oil palm (Elaeis guineensis) population by Seng, Tzer Ying

“…The many QTLs detected per trait suggested that the traits studied are polygenic with many genes of individual small effects on independent loci. …”
Get full text

Characterization of nickel-titanium based thin films crystallized by fast and ultra-fast annealing methods by Motemani Sharabiani, Yahya

“…The decrease in transformation temperature is caused by the fine nano-scale structure in Ti-Ni-Hf thin samples. …”
Get full text

牛车水的塑造：政治活动中华人的自主性和殖民管治 = The shaping of Chinatown: relationship of Chinese agency and colonial governance in political activities by 蔡晓欣 Choi, Irene Hiu Yan

“…Through this approach, it is of the hope to enrich the historiography and shine the spotlight on this group of people who lived earnestly in Singapore as well as demonstrate the complexity between people and place.…”
Get full text

Towards semantic, debiased and moment video retrieval by Satar, Burak

“…Our approach tackles this challenge for the first time on long, fine-grained, and untrimmed egocentric videos, while existing methodologies target short, coarse-grained, and trimmed third-person videos. …”
Get full text