Evidence-Based Second-Line Treatment in RAS Wild-Type/Mutated Metastatic Colorectal Cancer in the Precision Medicine Era by Guido Giordano, Pietro Parcesepe, Giuseppina Bruno, Annamaria Piscazzi, Vincenzo Lizzi, Andrea Remo, Massimo Pancione, Mario Rosario D’Andrea, Elena De Santis, Luigi Coppola, Michele Pietrafesa, Alberto Fersini, Antonio Ambrosi, Matteo Landriscina

Get full text

Evaluation of Epithelial–Mesenchymal Transition Markers in Autoimmune Thyroid Diseases by Pablo Sacristán-Gómez, Ana Serrano-Somavilla, Lía Castro-Espadas, Nuria Sánchez de la Blanca Carrero, Miguel Sampedro-Núñez, José Luis Muñoz-De-Nova, Francisca Molina-Jiménez, Alejandra Rosell, Mónica Marazuela, Rebeca Martínez-Hernández

Get full text

Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…However, the trial was deemed exploitative by a public watch group when it was revealed that the drug was already FDA-approved in the United States, and the manufacturer of that drug was undertaking another study with the same drug in Europe without any placebos. …”
Get full text

Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…However, the trial was deemed exploitative by a public watch group when it was revealed that the drug was already FDA-approved in the United States, and the manufacturer of that drug was undertaking another study with the same drug in Europe without any placebos. …”
Get full text

Availability of technology for managing cancer patients in the Southeast European (SEE) region by Manjit Dosanjh, Mimoza Ristova, Vesna Gershan, Petya Georgieva, Marijana Balin Kovacevic, Ledio Bregu, Irma Coralic, Tamara Djurovic, Deyana Dosieva, Yiota Foka, Ana Fröbe, Konstantinos Hatziioannou, Costas J. Hourdakis, Yllka Kabashi, Dimitar Kalev, Ilir Kurtishi, Leandar Litov, Beqir Mezelxhiu, Svetlana Nestoroska Madjunarova, Gordana Nikolova, Damijan Skrk, Velda Smajlbegovic, Snezana Smichkoska, Igor Stojkovski, Primož Strojan, Zdravka Tecic, Dušanka Tešanović, Vladimir Todorovic, Zdravka Valerianova

Get full text

South Asian Muslim politics, 1937-1958 by Samad, Y, Yunas Samad

“…The 1937 elections initiated a major political shift among the Muslim regional parties and caused great unease among the urban groupings. …”

Drivers and barriers to change in desalinated water governance in the GCC: a comparative approach to water privatisations in Abu Dhabi, Doha and Kuwait City by Lambert, LA

“…</p> <p>This thesis investigates the drivers, barriers and counter-forces to a major institutional change - privatisation - in the desalinated water governance of the coastal cities of the Gulf Cooperation Council (GCC) region. …”

Evaluation of Efficiency and Returns to Scale of Resin Chemical Industry Supply Chain using Crisp and Fuzzy Data Envelopment by Faranak Hosseinzadeh Saljooghi, Amir Rahimi

“…Planning, purchasing, production, transportation, storage, distribution and customer service are parts of supply chain which have a major role in the process of running any business. …”
Get full text

High performance database systems on coupled CPU-GPU architectures by He, Jiong

“…In recent years, programming on GPUs for general-purpose tasks has been significantly simplified with the release of programming interfaces. …”
Get full text

Prioritization of the Eelements Affecting Urban Environmental Quality in Shiraz by Mahshid MohammadEbrahimi, Amir Oshnooei Nooshabadi

“…Assessing urban environmental quality change of Indianapolis, United States, by the remote sensing and GIS integration. …”
Get full text

Different populations of A(H1N1)pdm09 viruses in a patient with hemolytic-uremic syndrome by Yuguang Fu, Marianne Wedde, Sigrun Smola, Djin-Ye Oh, Thorsten Pfuhl, Jürgen Rissland, Michael Zemlin, Fidelis A. Flockerzi, Rainer M. Bohle, Andrea Thürmer, Susanne Duwe, Barbara Biere, Janine Reiche, Brunhilde Schweiger, Christin Mache, Thorsten Wolff, Georg Herrler, Ralf Dürrwald

Get full text

Identification and Assessment of the Emotional Divorce Drivers among Tehranian Couples Based on the Experts’ Views Using a Multi-Criteria Decision-Making (MCDM) Approach by Parvin Arbabzadeh, Shahla Kazemipour, Seyed Reza Moini

“…Efforts to strengthen the couple's bond and the relationships within this system provide moral health and general prosperity. However, this relationship has undergone various changes over time and the ups and downs of life, which leave major results. …”
Get full text

Pembangunan projek penswastaan tanah negeri Johor by Hariss, Natazha

“…Privatization is generally defined as the transfer of activities and functions, especially in the field of infrastructure development, which is managed by the government of a state to the private sector for the purpose of improving management efficiency, increase productivity and ensure sustainable economic future. …”
Get full text

Methods of Cinematic Narrative in Today’s Ghazal by Mohsen Mohammadi fesharaki, Pante'a Safaee

“…Although sometimes, knowing allusions and metaphors in Persian language makes most of the audiences enjoy poetry, but instead, loss of pleasure in understanding this lyric narrative is not due to ironic and metaphorical decoding.   3- Narrative in lyric helps Ghazal to consider details instead of general and diverse subjects, and u sing this purposeful ordering of the details, it goes to the state of general issues. …”
Get full text

Technical, Pure Technical and Scale Efficiency: A Non-Parametric Approach of Pakistans Insurance and Takaful Industry by Taib, Che Azlan, Ashraf, Muhammad Saleem, Ahmad Razimi, Mohd Shahril

“…At the time of independence in 1947, 84 insurance companies were operative in Pakistan but the insurance industry was nationalized in 1972 and merged into State Life of Pakistan. However there was a major breakthrough in the 1990s, the financial reforms took into place and these reforms allowed private and foreign companies to establish their business in the insurance sector (Malik, Malik & Faridi, 2011; "State Bank of Pakistan", 2005). …”

Common variable immunodeficiency in two kindreds with heterogeneous phenotypes caused by novel heterozygous NFKB1 mutations by Frederik Staels, Frederik Staels, Kerstin De Keukeleere, Kerstin De Keukeleere, Matias Kinnunen, Salla Keskitalo, Flaminia Lorenzetti, Flaminia Lorenzetti, Michiel Vanmeert, Teresa Prezzemolo, Emanuela Pasciuto, Emanuela Pasciuto, Eveline Lescrinier, Xavier Bossuyt, Margaux Gerbaux, Mathijs Willemsen, Julika Neumann, Sien Van Loo, Anniek Corveleyn, Karen Willekens, Ingeborg Stalmans, Isabelle Meyts, Isabelle Meyts, Adrian Liston, Adrian Liston, Stephanie Humblet-Baron, Mikko Seppänen, Markku Varjosalo, Rik Schrijvers, Rik Schrijvers

Get full text

Association of improved oxidative stress tolerance and alleviation of glucose repression with superior xylose-utilization capability by a natural isolate of Saccharomyces cerevisia... by Cheng Cheng, Rui-Qi Tang, Liang Xiong, Ronald E. Hector, Feng-Wu Bai, Xin-Qing Zhao

Get full text

Reconceptualizing Professionalism in the Context of Acupuncture: Setting Standards for Future Acupuncturists, a View from Malaysia by Chee Hee Seng, Linchao Qian, Yun Jin Kim

“…During the Covid-19 pandemic, hospitals are understaffed and have to work with sleep deprivation, excessive or conflicting job demands, long hours, and an imbalance between work and home life.6 Suicide rates appear higher among doctors than in other occupations. In the United States, estimates suggest one physician dies by suicide every day. …”
Get full text

The Care Home Independent Pharmacist Prescriber Study (CHIPPS): development and implementation of an RCT to estimate safety, effectiveness and cost-effectiveness by David Wright, Richard Holland, David Phillip Alldred, Christine Bond, Carmel Hughes, Garry Barton, Fiona Poland, Lee Shepstone, Antony Arthur, Linda Birt, Jeanette Blacklock, Annie Blyth, Stamatina Cheilari, Amrit Daffu-O’Reilly, Lindsay Dalgarno, James Desborough, Joanna Ford, Kelly Grant, Janet Gray, Christine Handford, Bronwen Harry, Helen Hill, Jacqueline Inch, Phyo Kyaw Myint, Nigel Norris, Maureen Spargo, Vivienne Maskrey, David Turner, Laura Watts, Arnold Zermansky

“…Care homes had to be caring for adults aged ≥65 years and associated with a participating general practice. Care home residents had to be under the care of a participating general practice, ≥65 years old and prescribed at least one regular medicine. …”
Get full text

Relationships between neuro-endocrine, electrocardiogram, and gastric mucosal damage parameters in naїve and stressed rats by Oksana Fihura, Oksana Melnyk, Sofiya Ruzhylo, Nataliya Zakalyak, Halyna Kondratska, Walery Zukow, Igor Popovych

Get full text