Mechanistic insights into the HPF1/PARP1 complex by Zobel, FFH

“…Crucially, colleagues and I describe the interaction sites on both proteins and show that HPF1 in cells is required for the catalytic completion of PARP1 through a glutamate "finger". Furthermore, we identify the main sites of PARP1 serine auto-modification and illustrate their significance for PARP inhibitor-resistant PARP1 auto-modification and the release of PARP1 from sites of DNA damage. …”

PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder by Wang, L

“…The resultant persistent single-strand breaks are processed via a back-up, PARP-dependent mechanism to ensure completion of lagging strand synthesis. …”

Role of Interferon-stimulated gene 15 (ISG15) in replication fork progression and PARP inhibitor resistance in cancer by Seung, Y

“…Understanding PARP (Poly-ADP ribose polymerase) inhibitor resistance is crucial in cancer therapy, particularly in treating cancers associated with BRCA mutations. …”

Identifying mechanisms involved in the resistance of homologous recombination defective Dictyostelium cells to ART inhibitors by Kolb, A

“…<p>Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) are toxic to cells with defects in homologous recombination (HR), which is exploited in the clinic as therapy of <em>BRCA1/2</em>-mutated tumours. …”

Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T-cells by Inayat-Hussain, Salmaan H., Osman, Annuar B., Din, Laily B., Ali, Abdul M.

“…Activation of these caspases was further evidenced by detection of poly(ADP-ribose) polymerase cleavage (PARP). Pre-treatment with the caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone (Z-VAD.FMK) blocked apoptosis and the resultant cleavage of these caspases and PARP. …”
Get full text

Zanthoxylum bungeanum essential oil induces apoptosis of HaCaT human keratinocytes by Li, K, Zhou, R, Wang Jia, W, Li, Z, Li, J, Zhang, P, Xiao, T

“…Western blot analysis was employed to estimate the expression level of proteins including caspase-8/9/3, PARP, Bax and Bcl-2. Results: Thirty-nine compounds of the ZBEO were identified GC-MS. …”

Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection by Kolinjivadi, Arun Mouli, Chong, Siao Ting, Choudhary, Ramveer, Sankar, Haresh, Chew, Ee Ling, Yeo, Claresta, Chan, Sock Hoai, Ngeow, Joanne

“…In RAD51C deficient chinese hamster CL-V4B cells, expression of RAD51C F164S, A87E, L134S and E49K variants heightened sensitivity to mitomycin C (MMC), etoposide and PARP inhibition. Differently, expression of a subset RAD51C variants R24L, R24W, and R212H displayed mild sensitivity to MMC, etoposide and PARP inhibition. …”
Get full text

Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells by Choi, Bo-Hwa, Kim, Wanil, Wang, Qiuxia Chelsia, Kim, Dong-Chan, Tan, Swee Ngin, Yong, Jean Wan Hong, Kim, Kyong-Tai, Yoon, Ho Sup

“…In contrast, human skin fibroblast CCL-116 and bovine primary fibroblast cells show resistances to KR and no significant changes in Bad, Bcl-XL, and cleaved PARP were observed. Our data suggest that KR selectively induces apoptosis in cancer cells through the classical mitochondria dependent apoptosis pathway.…”
Get full text
Get full text

Ruthenium(ii) Polypyridyl complexes as FRET donors: structure- and sequence-selective DNA binding and anti-cancer properties by E. Elgar, Christopher, Yusoh, Nur Aininie, R. Tiley, Paul, Kolozsvári, Natália, G. Bennett, Laura, Gamble, Amelia, V. Péan, Emmanuel, L. Davies, Matthew, J. Staples, Christopher, Ahmad, Haslina, R. Gill, Martin

“…Molecules characterized by this method demonstrate encouraging anticancer properties, including synergy with the PARP inhibitor Olaparib, and mechanistic studies indicate that [Ru(PIP)2(5,5′dmb)]2+ acts to block DNA replication fork progression.…”

Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Nurkolis, Fahrul, Kurniatanty, Isma, Wiyarta, Elvan, Permatasari, Happy Kurnia, Mayulu, Nelly, Taslim, Nurpudji Astuti, Tjandrawinata, Raymond Rubianto, Hardinsyah, Hardinsyah, Tallei, Trina Ekawati, Tsopmo, Apollinaire, Radu, Son, Hadinata, Edwin, Kim, Bonglee, Ribeiro, Rosy Iara Maciel Azambuja, Syahputra, Rony Abdi

“…The most promising compound was avenasterol binding PARP-1, HER2, iNOS receptors with values of −11.26, −8.34, and −9.17 μg/mL, respectively. …”
Get full text

Mendelian randomization identifies proteins involved in neurodegenerative diseases by Belbasis, L, Morris, S, Van Duijn, C, Bennett, D, Walters, R

“…The newly-associated proteins indicated the involvement of complement (C1S, C1R), microglia (SIRPA, SIGLEC9, PRSS8) and lysosomes (CLN5) in AD, interleukin-6 pathway (CTF1) in PD, lysosomes (TPP1), blood–brain barrier integrity (MFAP2) and astrocytes (TNFSF13) in ALS, and blood–brain barrier integrity (VEGFB), oligodendrocytes (PARP1), node of Ranvier and dorsal root ganglion (NCS1, FLRT3, CDH15), and innate immune system (CR1, AHSG, WARS) in MS. …”

Suppression of electronic correlations by chemical pressure from FeSe to FeS (ARPES_FeSeS 2017) by Coldea, A, Reiss, P