Single-molecule diagnostics to support curative interventions for tuberculosis and HIV by Dougan, Tyler J.

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Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine learning approaches by Carter, J, Walker, T, Walker, A, Whitfield, M, Morlock, G, Lynch, C, Adlard, D, Peto, T, Posey, J, Crook, D, Fowler, P

“…<p><strong>Methods</p></strong> We curated a dataset of 664 non-redundant, missense amino acid mutations in PncA with associated high-confidence phenotypes from published studies and then trained three different machine-learning models to predict pyrazinamide resistance. …”

Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Part II: Small Peptide and Membrane Lipid Based Self-assembled Nanostructures for Controlled Drug/gene Delivery The usage of nanoscale materials may greatly facilitate the development of novel therapeutic methods for controllable release of bioactive agents at location of diseases with desired dosage, which has been considered to be of clinical significance to guarantee the curative effect while minimizing the drug resistance and other side effects.8-10 Among the available nanocarriers, the self-assembled nanostructures from highly biocompatible materials (e.g. oligo-peptide, membrane lipids, etc) have been extensively studied due to their unique features of high water content, high drug/gene loading efficiency and promising therapeutic effect.11-13 More importantly, they are naturally biocompatible and biodegradable thus ensuring desirable bio-safety, whereas in terms of inorganic nanoparticle-based delivery systems, additional surface modifications were often required to achieve a good biocompatibility. …”
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Inorganic nanoparticles–driven self–assembly of natural small molecules in water for constructing multifunctional nanocapsules against plant diseases by Liu, Li-Wei, Ding, Zheng-Hao, Ren, Gang-Gang, Wang, Guang-Di, Pan, Xin, Wei, Guo-Hai, Zhou, Xiang, Wu, Zhi-Bing, Jin, Zhi-Chao, Chi, Robin Yonggui, Yang, Song

“…ZnO@Cur@PDA display strong activities against rice bacterial blight with protective activity of 64.0 % and curative activity of 62.2%, which is much better than commercial drugs bismerthiazol (protective activity of 33.0 % and curative activity of 38.4%) and zinc thiazole(protective activity of 38.6 % and curative activity of 31.8%). …”
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Disrupting Monocultural Tendencies through Multimodal Montage by Singha, Mrinalini

“…Through a curated assemblage of works, the exhibition provided a physical space for interaction, reflection, and conversation, enabling audiences to engage with the themes of the thesis viscerally. …”
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

“…However, many patients still fail to show a clinically meaningful response to kinase inhibitors prescribed on the basis of tumor genotype, and nearly all responsive patients eventually develop resistance, limiting the curative potential of these agents. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…While there are few clinically approved anti-IAV drugs for therapeutic and prophylactic use, these drugs have also been challenged by the emergence of drug resistance, toxicity, adverse effects and low efficacy. …”
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