Conventions and the stock market game by Fuggetta, M, Fuggetta, Massimo

“…<p>Forecasting stock price movements is a notoriously difficult job. Were it not so, it would be easy to get richer. …”

Old Tools, New Ways of Using Them: Harnessing Expert Opinions to Plan for Surprise in Marine Socio-Ecological Systems by Rebecca V. Gladstone-Gallagher, Rebecca V. Gladstone-Gallagher, Julie A. Hope, Richard H. Bulmer, Dana E. Clark, Dana E. Clark, Fabrice Stephenson, Stephanie Mangan, Vera Rullens, Ewa Siwicka, Samuel F. Thomas, Conrad A. Pilditch, Candida Savage, Candida Savage, Simon F. Thrush

“…Consequently, marine ecosystems are notoriously difficult to manage, and scientists, managers, and policy makers are paralyzed in a spiral of ecosystem degradation. …”
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Aerial photogrammetry to characterise and numerically model an ice jam in Southern Quebec by Jason Duguay, Karl-Erich Lindenschmidt, Mélanie Trudel, Antoine Pruneau

“…Collecting data on the dynamic breakup of a river's ice cover is a notoriously difficult task. However, such data are necessary to reconstruct the events leading to the formation of ice jams and calibrate numerical ice jam models. …”
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On the variability and forced response of atmospheric regime systems by Dorrington, JCF

“…</p> <p>This thesis contributes to bridging this divide by working across the model hierarchy to compare the behaviour of simple and complex regime systems. …”

Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through by Amirah Syamimi Jusop, Kalaiselvaan Thanaskody, Gee Jun Tye, Sylvia Annabel Dass, Wan Safwani Wan Kamarul Zaman, Fazlina Nordin

“…Therefore, alternative models of human or animal cells have been developed to bridge the gap and allow the impact of new therapeutic strategies to be anticipated more accurately by trying to mimic neuronal and glial cell interactions and many more mechanisms. …”
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Conditional Variational AutoEncoder based on Stochastic Attacks by Gabriel Zaid, Lilian Bossuet, Mathieu Carbone, Amaury Habrard, Alexandre Venelli

“…In this work, we propose the first solution that bridges DL and SCA in order to get this security bound. …”
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Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias by Emma T. van der Westhuizen, K. H. Christopher Choy, Celine Valant, Simon McKenzie-Nickson, Sophie J. Bradley, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos

“…Indeed, recent studies in mice suggest that allosteric modulators for the M1 mAChR that bias signaling toward specific pathways may be therapeutically important. This review brings together details on the signaling pathways activated by the M1 and M4 mAChRs, evidence of biased agonism at these receptors, and highlights pathways that may be important for developing new subtype selective allosteric ligands to achieve therapeutic benefit.…”
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Procedural- and Reinforcement-Learning-Based Automation Methods for Analog Integrated Circuit Sizing in the Electrical Design Space by Yannick Uhlmann, Michael Brunner, Lennart Bramlage, Jürgen Scheible, Cristóbal Curio

“…Analog integrated circuit sizing is notoriously difficult to automate due to its complexity and scale; thus, it continues to heavily rely on human expert knowledge. …”
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Improving acquisition speed and efficiency of advanced arterial spin labelling MRI by Schauman, SS

“… <p>Magnetic resonance imaging (MRI) is a notoriously slow imaging method compared with other imaging modalities, for example computed tomography. …”

Estimating the global burden of endemic canine rabies. by Katie Hampson, Laurent Coudeville, Tiziana Lembo, Maganga Sambo, Alexia Kieffer, Michaël Attlan, Jacques Barrat, Jesse D Blanton, Deborah J Briggs, Sarah Cleaveland, Peter Costa, Conrad M Freuling, Elly Hiby, Lea Knopf, Fernando Leanes, François-Xavier Meslin, Artem Metlin, Mary Elizabeth Miranda, Thomas Müller, Louis H Nel, Sergio Recuenco, Charles E Rupprecht, Carolin Schumacher, Louise Taylor, Marco Antonio Natal Vigilato, Jakob Zinsstag, Jonathan Dushoff, Global Alliance for Rabies Control Partners for Rabies Prevention

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Non‐invasive mark–resight surveys for brown bears: Incorporating spatial information to improve landscape‐scale monitoring of density and distribution by Joshua H. Schmidt, William W. Deacy, Letty J. Hughes, Dylan T. Schertz

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The Key Role of No-Carbon National Oil Companies in Global Climate Action: Leveraging The G20 Forum to Accelerate Energy Transition by Leonardo Beltrán-Rodríguez, Juan Roberto Lozano-Maya

“…Cognizant of this potential, in recent years several international oil companies (IOCs), publicly traded organizations with large capital access and wide geographical reach, have looked to effectively reduce their carbon intensity by shifting their operations to non-core low- carbon energy development. In addition to bringing about positive climate-driven outcomes, the IOCs that have embraced this energy transition strive to leverage business opportunities presented by political and social environments which are progressively more aware of the energy sector’s contributions to climate change. …”
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Development of Epipolythiodiketopiperazine syntheses and the total synthesis of diketopiperazine alkaloids by Adams, Timothy C. (Timothy Cho)

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Everolimus decreases [U-13C]glucose utilization by pyruvate carboxylase in breast cancer cells in vitro and in vivo by Gerke Ariaans, Jiske F. Tiersma, Bernardus Evers, Albert Gerding, Stijn J.H. Waaijer, Remco A. Koster, Daan J. Touw, Barbara M. Bakker, Dirk-Jan Reijngoud, Steven de Jong, Mathilde Jalving

“…Reprogrammed metabolism is a hallmark of cancer, but notoriously difficult to target due to metabolic plasticity, especially in response to single metabolic interventions. …”
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Using Deep Learning to Understand and Design Heterogeneous Materials by Yang, Zhenze

“…At the atomic scale, we utilize a graph neural network based method to bridge structural defects and the distribution of atomic properties in mesoscale crystalline solids. …”
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Turning the tide: comparison of tidal flow by periodic sea level fluctuation and by periodic bed tilting in scaled landscape experiments of estuaries by M. G. Kleinhans, M. van der Vegt, J. Leuven, L. Braat, H. Markies, A. Simmelink, C. Roosendaal, A. van Eijk, P. Vrijbergen, M. van Maarseveen

“…Analogue models or scale experiments of estuaries and short tidal basins are notoriously difficult to create in the laboratory because of the difficulty to obtain currents strong enough to transport sand. …”
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COVID-19 in conflict region: the arab levant response by Nazih A. Bizri, Walid Alam, Tala Mobayed, Hani Tamim, Maha Makki, Umayya Mushrrafieh

“…The combination of war, conflict, and a pandemic brings too much of a burden for any nation to handle. …”
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