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Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease
Published 2024“…Here, we combined quantitative mass spectrometry, cryo-electron tomography and single-particle cryo-electron microscopy to study brain EVs from individuals with AD. We found tau filaments composed mainly of truncated tau that were enclosed within EVs enriched in endo-lysosomal proteins. …”
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Hominin brain size increase has emerged from within-species encephalization
Published 2024“…Using a phylogenetic approach never applied before to paleoanthropological data, we show that relative brain size increase across ~7 My of hominin evolution arose from increases within individual species which account for an observed overall increase in relative brain size. …”
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Identifying independent sub-networks of functional connectome of the brain
Published 2015“…By using FMRI scans, we are able to observe the Blood Oxygenation Level Dependent (BOLD) signals within the resting brain and derive patterns from it. …”
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Final Year Project (FYP) -
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Defining a critical period for inhibitory circuits within the somatosensory cortex
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Journal Article -
5
Transcriptional brain networks and their key regulators across the human lifespan
Published 2014“…The dynamics of global network metrics indicated strong coordination of expression across the lifespan compared to similar variance within age groups. This work shows that the transcriptome of human post-mortem brains at least partially preserves the network structure of cell types and functionally related genes, and how it may be dissected using suitable combinations of bioinformatic algorithms.…”
Thesis -
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Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection
Published 2024“…<br> Collectively, these data point to functionally divergent humoral responses depending on the site of infection (i.e. lungs versus brain) and demonstrate a highly compartmentalized <i>M. tuberculosis</i>-specific antibody response within the CSF in TBM. …”
Journal article -
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Normative modeling of brain morphometry in clinical high risk for psychosis
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Journal Article -
8
A multimodal neural signature of face processing in autism within the fusiform gyrus
Published 2025“…Its neural correlates have been explored extensively across single neuroimaging modalities within key regions of the face processing network, such as the fusiform gyrus (FFG). …”
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Imagining the Voltage of Neurons Distributed Across Entire Brains of Larval Zebrafish
Published 2024“…However, due to the high imaging speed and signal-to-noise ratio requirements of GEVIs, microscopy hardware to date has only been able to image the voltage of neurons within subregions of the brain, even for small animals like the larval zebrafish. …”
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Thesis -
10
An Exploratory Study of Large-Scale Brain Networks during Gambling Using SEEG
Published 2024“…However, the connectivity of large-scale brain networks during decision-making is not well understood. …”
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Article -
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Opto-electrical bimodal recording of neural activity in awake head-restrained mice
Published 2022“…Electrical and optical monitoring of neural activity is major approaches for studying brain functions. Each has its own set of advantages and disadvantages, such as the ability to determine cell types and temporal resolution. …”
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Journal Article -
12
Technological Innovation and Integration of Whole Brain Imaging, Olfactory Stimulation, and Correlative Microscopy in Larval Zebrafish
Published 2024“…Towards this end, this thesis presents novel approaches and technologies for whole-brain imaging, olfactory stimulation, and correlative imaging---i.e. the utilization and registration of multiple imaging modalities within a single sample. …”
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Thesis -
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Functional and effective connectivity study of the human brain topology using a novel unifying framework
Published 2023“…There has been a rapid expansion of neuroscientific research employing brain connectivity analysis. Among these are studies unravelling the neural mechanisms of brain diseases and treatments. …”
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Thesis -
14
Growth hormone increases BDNF and mTOR expression in specific brain regions after photothrombotic stroke in mice
Published 2023“…Conclusion. r-hGH increases pro-BDNF within the peri-infarct area and regions that are known to experience secondary neurodegeneration after stroke. …”
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Journal Article -
15
Transferring a deep learning model from healthy subjects to stroke patients in a motor imagery brain-computer interface
Published 2024“…Objective. Motor imagery (MI) brain-computer interfaces (BCIs) based on electroencephalogram (EEG) have been developed primarily for stroke rehabilitation, however, due to limited stroke data, current deep learning methods for cross-subject classification rely on healthy data. …”
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Journal Article -
16
fNIRS reveals enhanced brain activation to female (versus male) infant directed speech (relative to adult directed speech) in Young Human Infants
Published 2018“…In a within-infant design, we assessed brain activity to female and male infant directed relative to adult directed speech in 4-month-old infants using fNIRS. …”
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Journal Article -
17
Kent Kiehl’s Search for the Criminal Brain America’s self-proclaimed “psychopath whisperer” says he can predict criminality in incarcerated people. Is the legal system buying it?...
Published 2024“…This thesis examines the research and claims of a prominent neuropsychologist within that historical context. He claims to have conducted promising brain research on incarcerated people that could uncover biological markers of criminal behavior, or even predict future criminality. …”
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Thesis -
18
HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis, Fall 2004
Published 2004Get full text
Learning Object -
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HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis, Fall 2006
Published 2006Get full text
Learning Object -
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HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis, Fall 2002
Published 2002Get full text
Learning Object