Chemical synthesis and expression of a gene coding for hirudin, the thrombin-specific inhibitor from the leech 'hirudo medicinalis' /
A DNA containing the coding sequence for the proteinase inhibitor protein hirudin from the leech 'Hirudo medicanalis' has been obtained by enzymic ligation of chemically synthesized deoxyoligonucleotides. The 226 bp synthetic gene carries signals for the translation initiation and terminat...
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