Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines

Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines

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Flavokawain B (1) is a natural chalcone extracted from the roots of Piper methysticum, and has been proven to be a potential cytotoxic compound. Using the partial structure of flavokawain B (FKB), about 23 analogs have been synthesized. Among them, compounds 8, 13 and 23 were found in new FKB deriva...

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Bibliographic Details
Main Authors: Addila, Abu Bakar, Akhtar, Muhammad Nadeem, Norlaily, Mohd Ali, Swee, Keong Yeap, Ching, Kheng Quah, Wan-Sin, Loh, Noorjahan Banu, Alitheen, Seema, Zareen, Ul-Haq, Zaheer, Syed Adnan, Ali Shah
Format: Article
Language:English
Published: MDPI - Open Access Publishing 2018
Subjects:
QP Physiology
Online Access:http://umpir.ump.edu.my/id/eprint/20646/7/Design%2C%20Synthesis%20and%20Docking%20Studies%20of%20Flavokawain%20B%20Type-fist-2018.pdf

Internet

http://umpir.ump.edu.my/id/eprint/20646/7/Design%2C%20Synthesis%20and%20Docking%20Studies%20of%20Flavokawain%20B%20Type-fist-2018.pdf

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