Loop protein engineering for improved transglycosylation activity of a β‐N Acetylhexosaminidase
Certain enzymes of the glycoside hydrolase family 20 (GH20) exert transglycosylation activity and catalyze the transfer of β‐N‐acetylglucosamine (GlcNAc) from a chitobiose donor to lactose to produce lacto‐N‐triose II (LNT2), a key human milk oligosaccharide backbone moiety. The present work is aime...
Main Authors: | Shariza, Jamek, Muschiol, Jan, Holck, Jesper, Zeuner, Birgitte, Busk, Peter K., Mikkelsen, Jørn D., Meyer, Anne S. |
---|---|
Format: | Article |
Language: | English |
Published: |
John Wiley & Sons
2018
|
Subjects: | |
Online Access: | http://umpir.ump.edu.my/id/eprint/22565/1/Loop%20protein%20engineering%20for%20improved%20transglycosylation%20activity.pdf |
Similar Items
-
Characterization of Two Novel Bacterial Type A exo-chitobiose Hydrolases Having C-terminal 5/12-type Carbohydrate-binding Modules
by: Shariza, Jamek, et al.
Published: (2017) -
Synthesis of eight stereoisomers of pochonicine: nanomolar inhibition of β-N-acetylhexosaminidases.
by: Zhu, J, et al.
Published: (2013) -
Nine of 16 stereoisomeric polyhydroxylated proline amides are potent β-N-acetylhexosaminidase inhibitors.
by: Ayers, B, et al.
Published: (2014) -
Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids
by: Glawar, A, et al.
Published: (2016) -
The synthesis and biological evaluation of novel N-acetylhexosaminidase inhibitors
by: Crabtree, E, et al.
Published: (2011)