Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

During tumor development and progression, intrinsic and extrinsic factors trigger endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the increased expression of molecular chaperones to cope with the stress and maintain tumor cell survival. Heat shock protein (HSP) GRP9...

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Bibliographic Details
Main Authors: Xiaofeng Duan, Stephen Iwanowycz, Soo Ngoi, Megan Hill, Qiang Zhao, Bei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
endoplasmic reticulum stress
cancer
chaperone
GRP94/GP96
biomarker
therapeutic target
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.629846/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.629846/full

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