Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

During tumor development and progression, intrinsic and extrinsic factors trigger endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the increased expression of molecular chaperones to cope with the stress and maintain tumor cell survival. Heat shock protein (HSP) GRP9...

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Bibliografische gegevens
Hoofdauteurs: Xiaofeng Duan, Stephen Iwanowycz, Soo Ngoi, Megan Hill, Qiang Zhao, Bei Liu
Formaat: Artikel
Taal:English
Gepubliceerd in: Frontiers Media S.A. 2021-04-01
Reeks:Frontiers in Oncology
Onderwerpen:
endoplasmic reticulum stress
cancer
chaperone
GRP94/GP96
biomarker
therapeutic target
Online toegang:https://www.frontiersin.org/articles/10.3389/fonc.2021.629846/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.629846/full

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