Preclinical ex-vivo Testing of Anti-inflammatory Drugs in a Bovine Intervertebral Degenerative Disc Model

Preclinical ex-vivo Testing of Anti-inflammatory Drugs in a Bovine Intervertebral Degenerative Disc Model

Discogenic low back pain (LBP) is a main cause of disability and inflammation is presumed to be a major driver of symptomatic intervertebral disc degeneration (IDD). Anti-inflammatory agents are currently under investigation as they demonstrated to alleviate symptoms in patients having IDD. However,...

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Bibliographic Details
Main Authors: Zhen Li, Yannik Gehlen, Fabian Heizmann, Sibylle Grad, Mauro Alini, R. Geoff Richards, David Kubosch, Norbert Südkamp, Kaywan Izadpanah, Eva Johanna Kubosch, Gernot Lang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
spine
regeneration
inflammation
intervertebral disc
disc degeneration
organ culture
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00583/full

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https://www.frontiersin.org/article/10.3389/fbioe.2020.00583/full

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