Wnt/β-catenin signaling activation promotes lipogenesis in the steatotic liver via physical mTOR interaction

Wnt/β-catenin signaling activation promotes lipogenesis in the steatotic liver via physical mTOR interaction

Background and aimsWnt/β-catenin signaling plays an important role in regulating hepatic metabolism. This study is to explore the molecular mechanisms underlying the potential crosstalk between Wnt/β-catenin and mTOR signaling in hepatic steatosis.MethodsTransgenic mice (overexpress Wnt1 in hepatocy...

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Bibliographic Details
Main Authors: Kewei Wang, Rong Zhang, Nadja Lehwald, Guo-Zhong Tao, Bowen Liu, Bo Liu, Yangseok Koh, Karl G. Sylvester
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Endocrinology
Subjects:
Wnt signaling
hepatic steatosis
fatty acid synthesis
high fat diet
beta-catenin (B-catenin)
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1289004/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1289004/full

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