Recovering What Matters: High Protein Recovery after Endotoxin Removal from LPS-Contaminated Formulations Using Novel Anti-Lipid A Antibody Microparticle Conjugates

Recovering What Matters: High Protein Recovery after Endotoxin Removal from LPS-Contaminated Formulations Using Novel Anti-Lipid A Antibody Microparticle Conjugates

Endotoxins or lipopolysaccharides (LPS), found in the outer membrane of Gram-negative bacterial cell walls, can stimulate the human innate immune system, leading to life-threatening symptoms. Therefore, regulatory limits for endotoxin content apply to injectable pharmaceuticals, and excess LPS must...

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Bibliographic Details
Main Authors: Cristiane Casonato Melo, Alexandra C. Fux, Martin Himly, Neus G. Bastús, Laura Schlahsa, Christiane Siewert, Victor Puntes, Albert Duschl, Isabel Gessner, Jonathan A. Fauerbach
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
LPS contamination
polystyrene particles
bioconjugation
supramolecular structures
LAL
NTA
Online Access:https://www.mdpi.com/1422-0067/24/18/13971

Internet

https://www.mdpi.com/1422-0067/24/18/13971

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