Evaluation of the SH-SY5Y cell line as an in vitro model for potency testing of a neuropeptide-expressing AAV vector

Evaluation of the SH-SY5Y cell line as an in vitro model for potency testing of a neuropeptide-expressing AAV vector

Viral vectors have become important tools for basic research and clinical gene therapy over the past years. However, in vitro testing of vector-derived transgene function can be challenging when specific post-translational modifications are needed for biological activity. Similarly, neuropeptide pre...

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Bibliographic Details
Main Authors: Jeanette Zanker, Daniela Hüser, Adrien Savy, Sara Lázaro-Petri, Eva-Maria Hammer, Christoph Schwarzer, Regine Heilbronn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
adeno-associated virus
gene therapy
neuropeptide
SH-SY5Y
differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1280556/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1280556/full

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