Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation

Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by accumulation of fragmented insoluble TDP-43 and loss of TDP-43 from the nucleus. Increased expression of exogenous TARDBP (encoding TDP-43) induces TDP-43 pathology and cytotoxicity, suggesting the involvement of abe...

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Bibliographic Details
Main Authors: Akihiro Sugai, Taisuke Kato, Akihide Koyama, Yuka Koike, Takuya Konno, Tomohiko Ishihara, Osamu Onodera
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
TDP-43
autoregulation
alternative splicing
antisense oligonucleotides
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302025

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http://www.sciencedirect.com/science/article/pii/S0969996119302025

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