Role of pyroptosis in spinal cord injury and its therapeutic implications
Background: Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosis is recognized as a new programmed cell death mechanis...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-02-01
|
| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123220301880 |
| _version_ | 1818615514805567488 |
|---|---|
| author | Abdullah Al Mamun Yanqing Wu Ilma Monalisa Chang Jia Kailiang Zhou Fahad Munir Jian Xiao |
| author_facet | Abdullah Al Mamun Yanqing Wu Ilma Monalisa Chang Jia Kailiang Zhou Fahad Munir Jian Xiao |
| author_sort | Abdullah Al Mamun |
| collection | DOAJ |
| description | Background: Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosis is recognized as a new programmed cell death mechanism regulated by the stimulation of caspase-1 and/or caspase-11/-4/-5 signaling pathways with a series of inflammatory responses. Aim: Our current review concisely summarizes the potential role of pyroptosis-regulated programmed cell death in SCI, according to several molecular and pathophysiological mechanisms. This review also highlights the targeting of pyroptosis signaling pathways and inflammasome components and its therapeutic implications for the treatment of SCI. Key scientific concepts: Multiple pieces of evidence have illustrated that pyroptosis plays significant roles in cell swelling, plasma membrane lysis, chromatin fragmentation and intracellular pro-inflammatory factors including IL-18 and IL-1β release. In addition, pyroptosis is directly mediated by the recently discovered family of pore-forming protein known as GSDMD. Current investigations have documented that pyroptosis-regulated cell death plays a critical role in the pathogenesis of multiple neurological disorders as well as SCI. Our narrative article suggests that inhibiting the pyroptosis-regulated cell death and inflammasome components could be a promising therapeutic approach for the treatment of SCI in the near future. |
| first_indexed | 2024-12-16T16:35:07Z |
| format | Article |
| id | doaj.art-000edc5fb0cb4dc0a4941e7444590188 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-12-16T16:35:07Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-000edc5fb0cb4dc0a4941e74445901882022-12-21T22:24:29ZengElsevierJournal of Advanced Research2090-12322021-02-012897109Role of pyroptosis in spinal cord injury and its therapeutic implicationsAbdullah Al Mamun0Yanqing Wu1Ilma Monalisa2Chang Jia3Kailiang Zhou4Fahad Munir5Jian Xiao6Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035 Zhejiang Province, ChinaInstitute of Life Sciences, Wenzhou University, Wenzhou, 325035 Zhejiang Province, ChinaDepartment of Pharmacy, Southeast University, Banani, Dhaka 1213, BangladeshPediatric Research Institute, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 Zhejiang Province, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 Zhejiang Province, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang Province, ChinaMolecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035 Zhejiang Province, China; Corresponding author.Background: Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosis is recognized as a new programmed cell death mechanism regulated by the stimulation of caspase-1 and/or caspase-11/-4/-5 signaling pathways with a series of inflammatory responses. Aim: Our current review concisely summarizes the potential role of pyroptosis-regulated programmed cell death in SCI, according to several molecular and pathophysiological mechanisms. This review also highlights the targeting of pyroptosis signaling pathways and inflammasome components and its therapeutic implications for the treatment of SCI. Key scientific concepts: Multiple pieces of evidence have illustrated that pyroptosis plays significant roles in cell swelling, plasma membrane lysis, chromatin fragmentation and intracellular pro-inflammatory factors including IL-18 and IL-1β release. In addition, pyroptosis is directly mediated by the recently discovered family of pore-forming protein known as GSDMD. Current investigations have documented that pyroptosis-regulated cell death plays a critical role in the pathogenesis of multiple neurological disorders as well as SCI. Our narrative article suggests that inhibiting the pyroptosis-regulated cell death and inflammasome components could be a promising therapeutic approach for the treatment of SCI in the near future.http://www.sciencedirect.com/science/article/pii/S2090123220301880Spinal cord injuryNeuroinflammationPyroptosisNLRP3Caspase-1Therapeutic implications |
| spellingShingle | Abdullah Al Mamun Yanqing Wu Ilma Monalisa Chang Jia Kailiang Zhou Fahad Munir Jian Xiao Role of pyroptosis in spinal cord injury and its therapeutic implications Journal of Advanced Research Spinal cord injury Neuroinflammation Pyroptosis NLRP3 Caspase-1 Therapeutic implications |
| title | Role of pyroptosis in spinal cord injury and its therapeutic implications |
| title_full | Role of pyroptosis in spinal cord injury and its therapeutic implications |
| title_fullStr | Role of pyroptosis in spinal cord injury and its therapeutic implications |
| title_full_unstemmed | Role of pyroptosis in spinal cord injury and its therapeutic implications |
| title_short | Role of pyroptosis in spinal cord injury and its therapeutic implications |
| title_sort | role of pyroptosis in spinal cord injury and its therapeutic implications |
| topic | Spinal cord injury Neuroinflammation Pyroptosis NLRP3 Caspase-1 Therapeutic implications |
| url | http://www.sciencedirect.com/science/article/pii/S2090123220301880 |
| work_keys_str_mv | AT abdullahalmamun roleofpyroptosisinspinalcordinjuryanditstherapeuticimplications AT yanqingwu roleofpyroptosisinspinalcordinjuryanditstherapeuticimplications AT ilmamonalisa roleofpyroptosisinspinalcordinjuryanditstherapeuticimplications AT changjia roleofpyroptosisinspinalcordinjuryanditstherapeuticimplications AT kailiangzhou roleofpyroptosisinspinalcordinjuryanditstherapeuticimplications AT fahadmunir roleofpyroptosisinspinalcordinjuryanditstherapeuticimplications AT jianxiao roleofpyroptosisinspinalcordinjuryanditstherapeuticimplications |