Polyphenols: From Theory to Practice
Background: The importance of polyphenols in human health is well known; these compounds are common in foods, such as fruits, vegetables, spices, extra virgin olive oil and wine. On the other hand, the different factors that modulate the biological activity of these compounds are less well known. Co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/10/11/2595 |
| _version_ | 1797510340645224448 |
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| author | Alberto Bertelli Marco Biagi Maddalena Corsini Giulia Baini Giorgio Cappellucci Elisabetta Miraldi |
| author_facet | Alberto Bertelli Marco Biagi Maddalena Corsini Giulia Baini Giorgio Cappellucci Elisabetta Miraldi |
| author_sort | Alberto Bertelli |
| collection | DOAJ |
| description | Background: The importance of polyphenols in human health is well known; these compounds are common in foods, such as fruits, vegetables, spices, extra virgin olive oil and wine. On the other hand, the different factors that modulate the biological activity of these compounds are less well known. Conceptualization of the work: In this review we took into account about 200 relevant and recent papers on the following topics: “polyphenols bioavailability”, “polyphenols matrix effect”, “food matrix effect”, “polyphenols-cytochromes interaction”, after having reviewed and updated information on chemical classification and main biological properties of polyphenols, such as the antioxidant, anti-radical and anti-inflammatory activity, together with the tricky link between in vitro tests and clinical trials. Key findings: the issue of polyphenols bioavailability and matrix effect should be better taken into account when health claims are referred to polyphenols, thus considering the matrix effect, enzymatic interactions, reactions with other foods or genetic or gender characteristics that could interfere. We also discovered that in vitro studies often underrate the role of phytocomplexes and thus we provided practical hints to describe a clearer way to approach an investigation on polyphenols for a more resounding transfer to their use in medicine. |
| first_indexed | 2024-03-10T05:30:07Z |
| format | Article |
| id | doaj.art-0011b79d697446f7b432aa9c8dcae302 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T05:30:07Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-0011b79d697446f7b432aa9c8dcae3022023-11-22T23:19:10ZengMDPI AGFoods2304-81582021-10-011011259510.3390/foods10112595Polyphenols: From Theory to PracticeAlberto Bertelli0Marco Biagi1Maddalena Corsini2Giulia Baini3Giorgio Cappellucci4Elisabetta Miraldi5Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, ItalyDepartment of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, ItalyDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, ItalyDepartment of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, ItalyDepartment of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, ItalyDepartment of Physical Sciences, Earth and Environment, University of Siena, 53100 Siena, ItalyBackground: The importance of polyphenols in human health is well known; these compounds are common in foods, such as fruits, vegetables, spices, extra virgin olive oil and wine. On the other hand, the different factors that modulate the biological activity of these compounds are less well known. Conceptualization of the work: In this review we took into account about 200 relevant and recent papers on the following topics: “polyphenols bioavailability”, “polyphenols matrix effect”, “food matrix effect”, “polyphenols-cytochromes interaction”, after having reviewed and updated information on chemical classification and main biological properties of polyphenols, such as the antioxidant, anti-radical and anti-inflammatory activity, together with the tricky link between in vitro tests and clinical trials. Key findings: the issue of polyphenols bioavailability and matrix effect should be better taken into account when health claims are referred to polyphenols, thus considering the matrix effect, enzymatic interactions, reactions with other foods or genetic or gender characteristics that could interfere. We also discovered that in vitro studies often underrate the role of phytocomplexes and thus we provided practical hints to describe a clearer way to approach an investigation on polyphenols for a more resounding transfer to their use in medicine.https://www.mdpi.com/2304-8158/10/11/2595polyphenolsbiological propertiesantioxidant and antiviral activitybioavailabilitypreclinical data |
| spellingShingle | Alberto Bertelli Marco Biagi Maddalena Corsini Giulia Baini Giorgio Cappellucci Elisabetta Miraldi Polyphenols: From Theory to Practice Foods polyphenols biological properties antioxidant and antiviral activity bioavailability preclinical data |
| title | Polyphenols: From Theory to Practice |
| title_full | Polyphenols: From Theory to Practice |
| title_fullStr | Polyphenols: From Theory to Practice |
| title_full_unstemmed | Polyphenols: From Theory to Practice |
| title_short | Polyphenols: From Theory to Practice |
| title_sort | polyphenols from theory to practice |
| topic | polyphenols biological properties antioxidant and antiviral activity bioavailability preclinical data |
| url | https://www.mdpi.com/2304-8158/10/11/2595 |
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