A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites
Abstract Protein evolution is constrained by structure and function, creating patterns in residue conservation that are routinely exploited to predict structure and other features. Similar constraints should affect variation across individuals, but it is only with the growth of human population sequ...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-04-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06117-5 |