Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis

Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis

Abstract Background Articular injection of mesenchymal stem cells (MSCs) has been applied to treat knee osteoarthritis (kOA), but its clinical outcomes are controversial. This study investigated whether an articular inflammatory microenvironment (AIM) impacts MSC-based therapy in a rat model of kOA....

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Bibliographic Details
Main Authors: Mengqiang Fan, Peijian Tong, Li Yan, Ting Li, Jiadan Ren, Jiefeng Huang, Wenxi Du, Li Zhou, Letian Shan
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Medicine
Subjects:
Knee osteoarthritis
Synovial fluid
Human umbilical cord mesenchymal stem cells
Articular inflammatory microenvironment
MMP13
c-Jun
Online Access:https://doi.org/10.1186/s12916-023-02923-6

Internet

https://doi.org/10.1186/s12916-023-02923-6

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