Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma

Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma

Summary: The DNAJ-PKAc fusion kinase is a defining feature of fibrolamellar carcinoma (FLC). FLC tumors are notoriously resistant to standard chemotherapies, with aberrant kinase activity assumed to be a contributing factor. By combining proximity proteomics, biochemical analyses, and live-cell phot...

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Bibliographic Details
Main Authors: Sophia M. Lauer, Mitchell H. Omar, Martin G. Golkowski, Heidi L. Kenerson, Kyung-Soon Lee, Bryan C. Pascual, Huat C. Lim, Katherine Forbush, F. Donelson Smith, John D. Gordan, Shao-En Ong, Raymond S. Yeung, John D. Scott
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000068

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http://www.sciencedirect.com/science/article/pii/S2211124724000068

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