Genome‐Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β‐Blockers

Genome‐Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β‐Blockers

BackgroundFor many indications, the negative chronotropic effect of β‐blockers is important to their efficacy, yet the heart rate (HR) response to β‐blockers varies. Herein, we sought to use a genome‐wide association approach to identify novel single nucleotide polymorphisms (SNPs) associated with H...

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Bibliographic Details
Main Authors: Mohamed H. Shahin, Daniela J. Conrado, Daniel Gonzalez, Yan Gong, Maximilian T. Lobmeyer, Amber L. Beitelshees, Eric Boerwinkle, John G. Gums, Arlene Chapman, Stephen T. Turner, Rhonda M. Cooper‐DeHoff, Julie A. Johnson
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atenolol
heart rate
metoprolol
pharmacogenomics
β‐blockers
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006463

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.006463

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