Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner.

Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner.

Endoplasmic reticulum (ER) stress is a common factor in the pathophysiology of diverse human diseases that are characterised by contrasting cellular behaviours, from proliferation in cancer to apoptosis in neurodegenerative disorders. Coincidently, dysregulation of AKT/PKB activity, which is the cen...

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Bibliographische Detailangaben
Hauptverfasser:	Hong Wa Yung, D Stephen Charnock-Jones, Graham J Burton
Format:	Artikel
Sprache:	English
Veröffentlicht:	Public Library of Science (PLoS) 2011-03-01
Schriftenreihe:	PLoS ONE
Online Zugang:	http://europepmc.org/articles/PMC3061875?pdf=render

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