Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment

Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment

Abstract A key element of risk assessment is accounting for the full range of variability in response to environmental exposures. Default dose-response methods typically assume a 10-fold difference in response to chemical exposures between average (healthy) and susceptible humans, despite evidence o...

Full description

Bibliographic Details
Main Authors: Julia R. Varshavsky, Swati D. G. Rayasam, Jennifer B. Sass, Daniel A. Axelrad, Carl F. Cranor, Dale Hattis, Russ Hauser, Patricia D. Koman, Emily C. Marquez, Rachel Morello-Frosch, Catherine Oksas, Sharyle Patton, Joshua F. Robinson, Sheela Sathyanarayana, Peggy M. Shepard, Tracey J. Woodruff
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Environmental Health
Subjects:
Adjustment factors
Chemicals
Cumulative risk
Environmental justice
EPA
NAMs
Online Access:https://doi.org/10.1186/s12940-022-00940-1

Internet

https://doi.org/10.1186/s12940-022-00940-1

Similar Items