RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis. As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels of extracellular matrix expression and hypoxia-related gene a...

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Bibliographic Details
Main Authors: Brianna Dufek, Daniel T Meehan, Duane Delimont, Kevin Wilhelm, Gina Samuelson, Ross Coenen, Jacob Madison, Edward Doyle, Brendan Smyth, Grady Phillips, Michael Anne Gratton, Dominic Cosgrove
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0237907

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https://doi.org/10.1371/journal.pone.0237907

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