Lipid Droplet Biosynthesis Impairment through DGAT2 Inhibition Sensitizes MCF7 Breast Cancer Cells to Radiation

Lipid Droplet Biosynthesis Impairment through DGAT2 Inhibition Sensitizes MCF7 Breast Cancer Cells to Radiation

Breast cancer is the most frequent cancer in women worldwide and late diagnosis often adversely affects the prognosis of the disease. Radiotherapy is commonly used to treat breast cancer, reducing the risk of recurrence after surgery. However, the eradication of radioresistant cancer cells, includin...

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Bibliographic Details
Main Authors: Clelia Nisticò, Francesca Pagliari, Emanuela Chiarella, Joana Fernandes Guerreiro, Maria Grazia Marafioti, Ilenia Aversa, Geraldine Genard, Rachel Hanley, Daniel Garcia-Calderón, Heather Mandy Bond, Maria Mesuraca, Luca Tirinato, Maria Francesca Spadea, Joao Carlos Seco
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
cancer stem cells
lipid metabolism
lipid droplet
DGAT2
radiotherapy
Online Access:https://www.mdpi.com/1422-0067/22/18/10102

Internet

https://www.mdpi.com/1422-0067/22/18/10102

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