Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

Abstract Background The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammati...

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Bibliographic Details
Main Authors: Raphaël Boursereau, Michel Abou-Samra, Sophie Lecompte, Laurence Noel, Sonia M. Brichard
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Biology
Subjects:
Adiponectin
miR-711
NLRP3 inflammasome
Skeletal muscle
Inflammation
Duchenne muscular dystrophy
Online Access:http://link.springer.com/article/10.1186/s12915-018-0501-z

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http://link.springer.com/article/10.1186/s12915-018-0501-z

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