Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators

Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators

Enadenotucirev (EnAd) is a chimeric group B adenovirus isolated by bioselection from a library of adenovirus serotypes. It replicates selectively in and kills a diverse range of carcinoma cells, shows effective anticancer activity in preclinical systems, and is currently undergoing phase I/II clinic...

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Bibliographic Details
Main Authors: Arthur Dyer, Ying Di, Hugo Calderon, Sam Illingworth, Gray Kueberuwa, Alison Tedcastle, Phil Jakeman, Suet Lin Chia, Alice Brown, Michael A. Silva, David Barlow, John Beadle, Terry Hermiston, David J.P. Ferguson, Brian Champion, Kerry D. Fisher, Leonard W. Seymour
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virus
adenovirus
oncosis
apoptosis
cell death
membrane permeabilization
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770516300523

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http://www.sciencedirect.com/science/article/pii/S2372770516300523

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