Effects on Dopaminergic Neurons Are Secondary in COX-Deficient Locomotor Dysfunction in Drosophila

Summary: Dopaminergic (DA) neurons have been implicated as key targets in neurological disorders, notably those involving locomotor impairment, and are considered to be highly vulnerable to mitochondrial dysfunction, a common feature of such diseases. Here we investigated a Drosophila model of locom...

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Bibliographic Details
Main Authors: Cagri Yalgin, Bohdana Rovenko, Ana Andjelković, Margot Neefjes, Burak Oymak, Eric Dufour, Ville Hietakangas, Howard T. Jacobs
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220305496