Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death

Abstract In humans, most neurons are born during embryonic development and have to persist throughout the entire lifespan of an individual. Thus, human neurons have to develop elaborate survival strategies to protect against accidental cell death. We set out to decipher the developmental adaptations...

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Main Authors: Ruven Wilkens, Anne Hoffrichter, Karolina Kleinsimlinghaus, Bettina Bohl, Carolin Haag, Nadja Lehmann, Malin Schmidt, Elena Muñoz Perez-Vico, Julia Wangemann, Klara Franziska Rehder, Sandra Horschitz, Georg Köhr, Julia Ladewig, Philipp Koch
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05340-4

Internet

https://doi.org/10.1038/s41419-022-05340-4

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