A 2-Pyridone-Amide Inhibitor Targets the Glucose Metabolism Pathway of <named-content content-type="genus-species">Chlamydia trachomatis</named-content>

A 2-Pyridone-Amide Inhibitor Targets the Glucose Metabolism Pathway of <named-content content-type="genus-species">Chlamydia trachomatis</named-content>

ABSTRACT In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120. A fluorescent KSK120 analogue was synthesized and observed to be associated with the C. trachomatis surface, suggesting that its target...

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Main Authors: Patrik Engström, K. Syam Krishnan, Bidong D. Ngyuen, Erik Chorell, Johan Normark, Jim Silver, Robert J. Bastidas, Matthew D. Welch, Scott J. Hultgren, Hans Wolf-Watz, Raphael H. Valdivia, Fredrik Almqvist, Sven Bergström
Format: Article
Language:English
Published: American Society for Microbiology 2015-02-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.02304-14

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https://journals.asm.org/doi/10.1128/mBio.02304-14

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