Calcium Export from Neurons and Multi-Kinase Signaling Cascades Contribute to Ouabain Neuroprotection in Hyperhomocysteinemia

Calcium Export from Neurons and Multi-Kinase Signaling Cascades Contribute to Ouabain Neuroprotection in Hyperhomocysteinemia

Pathological homocysteine (HCY) accumulation in the human plasma, known as hyperhomocysteinemia, exacerbates neurodegenerative diseases because, in the brain, this amino acid acts as a persistent <i>N</i>-methyl-<span style="font-variant: small-caps;">d</span>-aspar...

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Bibliographic Details
Main Authors: Maria A. Ivanova, Arina D. Kokorina, Polina D. Timofeeva, Tatiana V. Karelina, Polina A. Abushik, Julia D. Stepanenko, Dmitry A. Sibarov, Sergei M. Antonov
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomolecules
Subjects:
homocysteine
glutamate
NMDA receptors
cortical neurons
ouabain
calcium
Online Access:https://www.mdpi.com/2218-273X/10/8/1104

Internet

https://www.mdpi.com/2218-273X/10/8/1104

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