Inhibition of Uncoupling Protein 2 Attenuates Cardiac Hypertrophy Induced by Transverse Aortic Constriction in Mice

Inhibition of Uncoupling Protein 2 Attenuates Cardiac Hypertrophy Induced by Transverse Aortic Constriction in Mice

Background: Uncoupling protein 2 (UCP2) is critical in regulating energy metabolism. Due to the significant change in energy metabolism of myocardium upon pressure overload, we hypothesize that UCP2 could contribute to the etiology of cardiac hypertrophy. Methods: Adult male C57BL/6J mice were subje...

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Bibliographic Details
Main Authors: Xiao-Bing Ji, Xiu-Rong Li, Hao-Ding, Qi Sun, Yang Zhou, Ping Wen, Chun-Sun Dai, Jun-Wei Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Uncoupling protein 2
Hypertrophy
Pressure overload
Genipin
Online Access:http://www.karger.com/Article/FullText/430142

Internet

http://www.karger.com/Article/FullText/430142

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