Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers
(1) Background: Little is known about the interlinkages between dietary and plasma non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and the body’s antioxidant and inflammation response. Our aim was to explore these associations in 210 participants from two Spanish European Prospe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/4/301 |
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| author | Cayetano Javier Carrión-García Eduardo Jesús Guerra-Hernández Belén García-Villanova Mauro Serafini María-José Sánchez Pilar Amiano Esther Molina-Montes |
| author_facet | Cayetano Javier Carrión-García Eduardo Jesús Guerra-Hernández Belén García-Villanova Mauro Serafini María-José Sánchez Pilar Amiano Esther Molina-Montes |
| author_sort | Cayetano Javier Carrión-García |
| collection | DOAJ |
| description | (1) Background: Little is known about the interlinkages between dietary and plasma non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and the body’s antioxidant and inflammation response. Our aim was to explore these associations in 210 participants from two Spanish European Prospective Investigation into Cancer and Nutrition (EPIC) centers. (2) Methods: D-NEAC was estimated using published NEAC values in food. P-NEAC and total polyphenols (TP) were quantified by FRAP (ferric-reducing antioxidant power), TRAP (total radical-trapping antioxidant parameter), TEAC-ABTS (trolox equivalent antioxidant capacity-Azino Bis Thiazoline Sulfonic), ORAC (oxygen radical absorbance capacity) and Folin–Ciocalteu assays. Nutrient antioxidants (carotenes, α-tocopherol, ascorbic acid, retinol, uric acid, Q9 and Q10 coenzymes) and inflammation markers (IL-6, IL-8, CRP, TNF-α, PAI-I, resistin and adiponectin) were also analyzed. Spearman correlation and linear regression analyses were performed in association analyses. Analyses were stratified by covariates and groups were defined using cluster analysis. (3) Results: P-FRAP was correlated with D-NEAC, and significantly associated with P-NEAC in multivariate adjusted models. P-FRAP levels were also significantly associated with plasma antioxidants (log2 scale: TP β = 0.26; ascorbic acid β = 0.03; retinol β = 0.08; α-tocopherol β = 0.05; carotenes β = 0.02; Q10 β = 0.06; uric acid β = 0.25), though not with inflammation-related biomarkers. Different profiles of individuals with varying levels of P-NEAC and biomarkers were found. (4) Conclusions: P-NEAC levels were to some extent associated with D-NEAC and plasma antioxidants, yet not associated with inflammation response. |
| first_indexed | 2024-03-10T20:39:25Z |
| format | Article |
| id | doaj.art-0036b4272c4945879811e70296cbef73 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T20:39:25Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-0036b4272c4945879811e70296cbef732023-11-19T20:45:59ZengMDPI AGAntioxidants2076-39212020-04-019430110.3390/antiox9040301Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related BiomarkersCayetano Javier Carrión-García0Eduardo Jesús Guerra-Hernández1Belén García-Villanova2Mauro Serafini3María-José Sánchez4Pilar Amiano5Esther Molina-Montes6Department of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja S/N, 18071 Granada, SpainDepartment of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja S/N, 18071 Granada, SpainDepartment of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja S/N, 18071 Granada, SpainFunctional Food and Metabolic Prevention Lab, Faculty of BioSciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, ItalyAndalusian School of Public Health, Instituto de Investigación Biosanitaria ibs.GRANADA, Univeristy Hospital of Granada/University of Granada, 18011 Granada, SpainCIBER Epidemiología y Salud Pública, CIBERESP (Centro de Investigación Biomédica), 28029 Madrid, SpainAndalusian School of Public Health, Instituto de Investigación Biosanitaria ibs.GRANADA, Univeristy Hospital of Granada/University of Granada, 18011 Granada, Spain(1) Background: Little is known about the interlinkages between dietary and plasma non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and the body’s antioxidant and inflammation response. Our aim was to explore these associations in 210 participants from two Spanish European Prospective Investigation into Cancer and Nutrition (EPIC) centers. (2) Methods: D-NEAC was estimated using published NEAC values in food. P-NEAC and total polyphenols (TP) were quantified by FRAP (ferric-reducing antioxidant power), TRAP (total radical-trapping antioxidant parameter), TEAC-ABTS (trolox equivalent antioxidant capacity-Azino Bis Thiazoline Sulfonic), ORAC (oxygen radical absorbance capacity) and Folin–Ciocalteu assays. Nutrient antioxidants (carotenes, α-tocopherol, ascorbic acid, retinol, uric acid, Q9 and Q10 coenzymes) and inflammation markers (IL-6, IL-8, CRP, TNF-α, PAI-I, resistin and adiponectin) were also analyzed. Spearman correlation and linear regression analyses were performed in association analyses. Analyses were stratified by covariates and groups were defined using cluster analysis. (3) Results: P-FRAP was correlated with D-NEAC, and significantly associated with P-NEAC in multivariate adjusted models. P-FRAP levels were also significantly associated with plasma antioxidants (log2 scale: TP β = 0.26; ascorbic acid β = 0.03; retinol β = 0.08; α-tocopherol β = 0.05; carotenes β = 0.02; Q10 β = 0.06; uric acid β = 0.25), though not with inflammation-related biomarkers. Different profiles of individuals with varying levels of P-NEAC and biomarkers were found. (4) Conclusions: P-NEAC levels were to some extent associated with D-NEAC and plasma antioxidants, yet not associated with inflammation response.https://www.mdpi.com/2076-3921/9/4/301total antioxidant capacitydietary antioxidantsantioxidant statusoxidative stressinflammatory markers |
| spellingShingle | Cayetano Javier Carrión-García Eduardo Jesús Guerra-Hernández Belén García-Villanova Mauro Serafini María-José Sánchez Pilar Amiano Esther Molina-Montes Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers Antioxidants total antioxidant capacity dietary antioxidants antioxidant status oxidative stress inflammatory markers |
| title | Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers |
| title_full | Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers |
| title_fullStr | Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers |
| title_full_unstemmed | Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers |
| title_short | Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers |
| title_sort | plasma non enzymatic antioxidant capacity neac in relation to dietary neac nutrient antioxidants and inflammation related biomarkers |
| topic | total antioxidant capacity dietary antioxidants antioxidant status oxidative stress inflammatory markers |
| url | https://www.mdpi.com/2076-3921/9/4/301 |
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