Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors

Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors

Neck dissection and/or elective nodal irradiation (ENI) are commonly performed in patients with head and neck squamous cell carcinoma (HNSCC) to minimize local and regional recurrence. However, here the authors show that ENI blunts the immune response to combined radiation and immunotherapy, increas...

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Bibliographic Details
Main Authors: Laurel B. Darragh, Jacob Gadwa, Tiffany T. Pham, Benjamin Van Court, Brooke Neupert, Nicholas A. Olimpo, Khoa Nguyen, Diemmy Nguyen, Michael W. Knitz, Maureen Hoen, Sophia Corbo, Molishree Joshi, Yonghua Zhuang, Maria Amann, Xiao-Jing Wang, Steven Dow, Ross M. Kedl, Von Samedi, Mary-Keara Boss, Sana D. Karam
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34676-w

Internet

https://doi.org/10.1038/s41467-022-34676-w

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