Population Pharmacokinetics of Valproic Acid in Pediatric and Adult Caucasian Patients

Population Pharmacokinetics of Valproic Acid in Pediatric and Adult Caucasian Patients

(1) Background: The aim of this study was to explore the valproic acid (VPA) pharmacokinetic characteristics in a large population of pediatric and adult Caucasian patients and to establish a robust population pharmacokinetic (PopPK) model. (2) Methods: A total of 2527 serum VPA samples collected fr...

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Bibliographic Details
Main Authors: Paulo Teixeira-da-Silva, Jonás Samuel Pérez-Blanco, Dolores Santos-Buelga, María José Otero, María José García
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
drug interactions
therapeutic drug monitoring
epilepsy
NONMEM
population pharmacokinetics
valproic acid
Online Access:https://www.mdpi.com/1999-4923/14/4/811

Internet

https://www.mdpi.com/1999-4923/14/4/811

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