Long-term survival of LGR5 expressing supporting cells after severe ototoxic trauma in the adult mouse cochlea

Long-term survival of LGR5 expressing supporting cells after severe ototoxic trauma in the adult mouse cochlea

IntroductionThe leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is a tissue resident stem cell marker, which it is expressed in supporting cells (SCs) in the organ of Corti in the mammalian inner ear. These LGR5+ SCs can be used as an endogenous source of progenitor cells for rege...

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Bibliographic Details
Main Authors: Natalia Smith-Cortinez, Ferry G. J. Hendriksen, Dyan Ramekers, Robert J. Stokroos, Huib Versnel, Louise V. Straatman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
inner ear regeneration
hearing loss
LGR5+ supporting cells
ototoxicity
adult mammalian cochlea
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1236894/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1236894/full

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