Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency

Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency

Common variable immunodeficiency (CVID), characterized by recurrent infections, low serum class-switched immunoglobulin isotypes, and poor antigen-specific antibody responses, comprises a heterogeneous patient population in terms of clinical presentation and underlying etiology. The diagnosis is reg...

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Bibliographic Details
Main Authors: Pauline van Schouwenburg, Susanne Unger, Kathryn J. Payne, Fabian M. P. Kaiser, Ingrid Pico-Knijnenburg, Jens Pfeiffer, Oliver Hausmann, David Friedmann, Michelle Erbel, Maximilian Seidl, David van Zessen, Andrew P. Stubbs, Mirjam van der Burg, Klaus Warnatz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
germinal center
common variable immunodeficiency (CVID)
B-cell differentiation
BCR repertoire analysis
secondary lymphoid organs (SLO)
plasma cell differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.959002/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.959002/full

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