Tailoring the implementation of new biomarkers based on their added predictive value in subgroups of individuals.

BACKGROUND:The value of new biomarkers or imaging tests, when added to a prediction model, is currently evaluated using reclassification measures, such as the net reclassification improvement (NRI). However, these measures only provide an estimate of improved reclassification at population level. We...

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Bibliographic Details
Main Authors: A van Giessen, K G M Moons, G A de Wit, W M M Verschuren, J M A Boer, H Koffijberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4306488?pdf=render