Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

Abstract Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer’s disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes (i.e., cognitive performance, N = 2233; brain age and AD-related si...

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Main Authors: Blanca Rodríguez-Fernández, Natalia Vilor-Tejedor, Eider M. Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Marc Suárez-Calvet, Grégory Operto, Carolina Minguillón, Karine Fauria, Gwendlyn Kollmorgen, Ivonne Suridjan, Manuel Castro de Moura, David Piñeyro, Manel Esteller, Kaj Blennow, Henrik Zetterberg, Immaculata De Vivo, José Luis Molinuevo, Arcadi Navarro, Juan Domingo Gispert, Aleix Sala-Vila, Marta Crous-Bou, for the ALFA study
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Cerebrospinal fluid biomarkers
Mendelian randomization
Neuroimaging
Polygenic risk score
Telomere length
Online Access:https://doi.org/10.1186/s13195-022-01101-9

Internet

https://doi.org/10.1186/s13195-022-01101-9

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