The rs11684747 and rs55790676 SNPs of ADAM17 influence tuberculosis susceptibility and plasma levels of TNF, TNFR1, and TNFR2

The rs11684747 and rs55790676 SNPs of ADAM17 influence tuberculosis susceptibility and plasma levels of TNF, TNFR1, and TNFR2

IntroductionThe proteolytic activity of A Disintegrin and Metalloproteinase 17 (ADAM17) regulates the release of tumor necrosis factor (TNF) and TNF receptors (TNFRs) from cell surfaces. These molecules play important roles in tuberculosis (TB) shaping innate immune reactions and granuloma formation...

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Main Authors: José Alberto Choreño-Parra, Lucero A. Ramon-Luing, Manuel Castillejos, Emmanuel Ortega-Martínez, Alan Rodrigo Tapia-García, Melvin Barish Matías-Martínez, Alfredo Cruz-Lagunas, Gustavo Ramírez-Martínez, Itzel Alejandra Gómez-García, Jazmín Ariadna Ramírez-Noyola, Beatriz Garcia-Padrón, Karen Gabriel López-Salinas, Fabiola Jiménez-Juárez, Parménides Guadarrama-Ortiz, Citlaltepetl Salinas-Lara, Karolina Bozena-Piekarska, Marcela Muñóz-Torrico, Leslie Chávez-Galán, Joaquín Zúñiga
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Microbiology
Subjects:
tuberculosis
ADAM17
TNF-α converting enzyme
tumor necrosis factor
tumor necrosis factor receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1392782/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1392782/full

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