A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors

A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors

IntroductionUse of adeno-associated virus (AAV) vectors is complicated by host immune responses that can limit transgene expression. Recent clinical trials using AAV vectors to deliver HIV broadly neutralizing antibodies (bNAbs) by intramuscular administration resulted in poor expression with anti-d...

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Bibliographic Details
Main Authors: Meredith E. Davis-Gardner, Jesse A. Weber, Jun Xie, Katja Pekrun, Eric A. Alexander, Kim L. Weisgrau, Jessica R. Furlott, Eva G. Rakasz, Mark A. Kay, Guangping Gao, Michael Farzan, Matthew R. Gardner
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
AAV (adeno-associated virus)
HIV - human immunodeficiency virus
SIV - simian immunodeficiency virus
antibody
anti-drug antibodies (ADA)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1105617/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1105617/full

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