Methylation of BDNF and SLC6A4 Gene Promoters in Brazilian Patients With Temporal Lobe Epilepsy Presenting or Not Psychiatric Comorbidities

Methylation of BDNF and SLC6A4 Gene Promoters in Brazilian Patients With Temporal Lobe Epilepsy Presenting or Not Psychiatric Comorbidities

The relationship between epilepsy and psychiatric comorbidities has been recognized for centuries, but its pathophysiological mechanisms are still misunderstood. It is biologically plausible that genetic or epigenetic variations in genes that codify important neurotransmitters involved in epilepsy a...

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Bibliographic Details
Main Authors: Isabel Cristina Bandeira, Lucas Giombelli, Isabel Cristina Werlang, Ana Lucia Abujamra, Thais Leite Secchi, Rosane Brondani, José Augusto Bragatti, Jorge Wladimir Junqueira Bizzi, Sandra Leistner-Segal, Marino Muxfeldt Bianchin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Integrative Neuroscience
Subjects:
methylation
psychiatric comorbidities
depression
BDNF
serotonin
neurotrophins
Online Access:https://www.frontiersin.org/articles/10.3389/fnint.2021.764742/full

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https://www.frontiersin.org/articles/10.3389/fnint.2021.764742/full

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